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ZoBio \- Drug Discovery Technology

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# ZoBio \- Drug Discovery Technology

Generated by Yoast SEO v28.5, this is an llms.txt file, meant for consumption by LLMs.

## Pages
- [Covalent Screening Services](https://zobio.com/covalent-screening-services/)
- [Home](https://zobio.com/)
- [Webinars](https://zobio.com/webinars/)
- [Capabilities](https://zobio.com/capabilities/)
- [About ZoBio](https://zobio.com/about-zobio/)

## Posts
- [ELRIG \(Drug Discovery 2026\)](https://zobio.com/geen-categorie/elrig-drug-discovery-2026/):  
- [Advancing Vaccine Research for the Prevention of Urinary Tract Infections](https://zobio.com/news/advancing-vaccine-research-for-the-prevention-of-urinary-tract-infections/): Urinary tract infections \(UTIs\) are among the most common bacterial infections worldwide, with extraintestinal pathogenic Escherichia coli \(ExPEC\) being a major causative agent\. The growing prevalence of antimicrobial resistance has increased the need for\.\.\.
- [Lessons Learned from Molecular Glue Discovery Campaigns \(Part 3\)](https://zobio.com/blog/lessons-learned-from-molecular-glue-discovery-campaigns-part-3/): Discovery of molecular glues is frequently perceived as serendipitous\. Drawing on 12 fragment\-based molecular glue screening campaigns across diverse protein pairs, we highlight here ten practical lessons that consistently influenced screening outcomes\.  In Part 1 and Part 2 of the series we have shown that intrinsic affinity between the protein matter and that cooperativity is key in finding moleucular glues\. We have shown that molecular glues are actually way more common than expected, provided that the screening assays are well set up\. In this Part\.\.\.
- [Lessons Learned from Molecular Glue Discovery Campaigns \(Part 2\)](https://zobio.com/blog/lessons-learned-from-molecular-glue-discovery-campaigns-part-2/): Discovery of molecular glues is frequently perceived as serendipitous\. Drawing on 12 fragment\-based molecular glue screening campaigns across diverse protein pairs, we highlight ten practical lessons that consistently influenced screening outcomes\.  In Part 1, we explored how intrinsic protein\-protein affinity and thermodynamic modelling can help establish sensitive molecular glue screens\. In Part 2, we turn to practical lessons from our screening campaigns, covering how to select suitable E3 ligases, identify cooperative hits, distinguish genuine glue\.\.\.
- [Lessons Learned from Molecular Glue Discovery Campaigns \(Part 1\)](https://zobio.com/blog/lessons-learned-from-molecular-glue-discovery-campaigns/): Discovery of molecular glues is frequently perceived as serendipitous\. Drawing on 12 fragment\-based molecular glue screening campaigns across diverse protein pairs, we discuss nine practical lessons that consistently influenced screening outcomes\. These include the role of intrinsic PPI affinity, cooperativity, quantitative characterization, hit triage and assay design\. While molecular glue discovery remains challenging, several principles can
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