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Valtoco (diazepam nasal spray)

VALTOCO (diazepam nasal spray) is a prescription medicine used for short-term treatment of seizure clusters (also known as "episodes of frequent seizure activity" or "acute repetitive seizures") that are different from a person's normal seizure pattern in people 2 years of age and older. See [Prescribing Information](https://valtoco.com/VALTOCO_Prescribing_Information.pdf) and [Medication Guide](https://valtoco.com/VALTOCO_Medication_Guide.pdf).

For agents: Prescription diazepam nasal spray for seizure clusters in patients 2 and older; provides prescribing information, medication guide and instructions for use.

diazepam nasal sprayseizure clustersepilepsy treatmentprescribing informationmedication guideacute repetitive seizures

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The beginning of the file, from our validated copy saved 2026-10-26T14:30:58.049Z. Cached copy · Source on valtoco.com

# Valtoco (diazepam nasal spray)

> VALTOCO (diazepam nasal spray) is a prescription medicine used for short-term treatment of seizure clusters (also known as "episodes of frequent seizure activity" or "acute repetitive seizures") that are different from a person's normal seizure pattern in people 2 years of age and older. See [Prescribing Information](https://valtoco.com/VALTOCO_Prescribing_Information.pdf) and [Medication Guide](https://valtoco.com/VALTOCO_Medication_Guide.pdf).

## IMPORTANT SAFETY INFORMATION

### What is the most important information I should know about VALTOCO?
* VALTOCO is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system (CNS) depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death. Get emergency help right away if any of the following happens:
    * Shallow or slowed breathing
    * Breathing stops (which may lead to the heart stopping)
    * Excessive sleepiness (sedation)
* Risk of abuse, misuse, and addiction. There is a risk for abuse, misuse, and addiction with benzodiazepines, including VALTOCO, which can lead to overdose and serious side effects including coma and death.
    * Serious side effects have happened in people who have abused or misused benzodiazepines, including diazepam (the active ingredient in VALTOCO). These serious side effects may also include delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these serious side effects.
    * Use VALTOCO exactly as your healthcare provider prescribed.

* Physical dependence and withdrawal reactions. Benzodiazepines, including VALTOCO, can cause physical dependence and withdrawal reactions, especially if you use VALTOCO daily. VALTOCO is not intended for daily use.
* VALTOCO can make you sleepy or dizzy and can slow your thinking and motor skills.
    * Do not drive, operate heavy machinery, or do other dangerous activities until you know how VALTOCO affects you.
    * Do not drink alcohol or take opioid medicines that make you sleepy or dizzy while taking VALTOCO until you talk to your healthcare provider. When taken with alcohol or medicines that can cause sleepiness or dizziness, VALTOCO may make your sleepiness or dizziness worse.
* Like other antiepileptic drugs, VALTOCO may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any new or worsening suicidal thoughts or related symptoms, especially unusual changes in mood, behaviors, thoughts or feelings.

### How can I watch for early symptoms of suicidal thoughts or actions?

* Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings.
* Keep all follow-up visits with your healthcare provider as scheduled.
* Call your
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