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Touch Medical Media Limited

For agents: Touch Medical Media oncology site with journal articles, ESMO congress previews and clinical news for cancer specialists.

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The beginning of the file, from our validated copy saved 2026-10-23T09:12:52.695Z. Cached copy · Source on touchoncology.com

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# Touch Medical Media Limited

## Sitemaps
- [XML Sitemap](https://touchoncology.com/sitemap_index.xml): Includes all crawlable and indexable pages.

## Journal Articles
- [The microbiome and mycobiome in esophageal cancer: Implications for pathogenesis, detection and treatment](https://touchoncology.com/gastrointestinal-cancers/journal-articles/the-microbiome-and-mycobiome-in-esophageal-cancer-implications-for-pathogenesis-detection-and-treatment/): Esophageal cancer (EC) is a major global health concern, ranking as the 11th most commonly diagnosed cancer and the seventh leading cause of cancer-related deaths worldwide, with an estimated 494,320 new cases and 441,994 deaths in 2024.1 Esophageal squamous cell carcinoma (ESCC) remains the predominant subtype globally (84% of new cases), while esophageal adenocarcinoma (EAC) now accounts for the majority of cases in high-income Western countries. ESCC predominates in Eastern Asia and parts of Africa, whereas EAC has risen sharply in the USA, Australia, Canada and several countries in Western and Northern Europe.2 These differences in geography and risk factor exposure suggest that ESCC and EAC are not simply histologic variants of one disease but biologically distinct malignancies shaped by different environmental exposures, host factors and local tissue microenvironments.
- [Perioperative management of urothelial carcinoma](https://touchoncology.com/bladder-cancer/journal-articles/perioperative-management-of-urothelial-carcinoma/): The benefit of perioperative treatment in MIBC is increasingly understood not only through survival gain but also through the depth of pathological response. Increasing attention has, therefore, shifted toward pCR as both a prognostic marker and a potential surrogate for long-term benefit. At ASCO GU 2025, Prof. Elizabeth Plimack highlighted that perioperative immunotherapy strategies must balance efficacy against overtreatment, particularly in patients who may already be cured by surgery and neoadjuvant therapy alone. Discussing updated results from CheckMate 274 and NIAGARA, she emphasized that adjuvant nivolumab now demonstrates a clear OS benefit in high-risk MIBC, while biomarkers such as ctDNA and PD-L1 expression may help identify which patients truly require escalation of therapy. She also questioned whether ‘sandwich’ perioperative chemoimmunotherapy approaches risk unnecessary toxicity, financial burden and prolonged treatment exposure when the individual contribution of adjuvant immunotherapy remains uncertain.50 This evolving response-adapted philosophy aligns with earlier work from Prof. Plimack in phase II RETAIN-1 and RETAIN-2 trials, which explored whether selected patients achieving clinical complete response (cCR) after NAC could safely proceed to active surveillance and avoid futile cystectomies.51–53 Similarly, Prof. Andreas Necchi’s
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