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The Lieber Institute for Brain Development | Research & Discovery

Unraveling the biological mechanisms behind mental illness.

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# The Lieber Institute for Brain Development | Research & Discovery

Unraveling the biological mechanisms behind mental illness.

## Sitemaps

- [XML Sitemap](https://www.libd.org/sitemap.xml): Contains all public & indexable URLs for this website.

## Posts

- [Biology of Suicide](https://www.libd.org/biology-of-suicide/) - Every year, almost 45,000 people give up hope and commit die by suicide, a painful act we stop to ponder every September during National Suicide Prevention Awareness Month. In the past few years, we have witnessed several high-profile celebrity suicides and staggering new data – a 30 percent rise in the number of people taking
- [Differential Expression: Mapping the Dysconnectivity Landscape of Schizophrenia Through Gene Co-Expression Network Topology](https://www.libd.org/differential-expression-mapping-the-dysconnectivity-landscape-of-schizophrenia-through-gene-co-expression-network-topology/) - A new study from the Lieber Institute for Brain Development reframes schizophrenia as a disorder of gene network architecture, and the implications for systems-level neuroscience are substantial. Introduction: Rethinking the Unit of Analysis The dominant paradigm in schizophrenia transcriptomics has long centered on differential gene expression, identifying genes whose abundance differs between cases and controls.
- [When Brain Cells Stop Listening to Each Other: New Research Unlocks a Hidden Key to Schizophrenia](https://www.libd.org/when-brain-cells-stop-listening-to-each-other-new-research-unlocks-a-hidden-key-to-schizophrenia/) - Scientists at the Lieber Institute for Brain Development have discovered that schizophrenia may be less about individual broken genes and more about how genes stop working together and the findings could change everything about how we treat this complex disorder. The Orchestra That Forgot How to Play Together Picture a world-class symphony orchestra. Each musician
- [Divergent Transcription in the BDNF Locus: Two Novel Genes That May Rewrite Our Understanding of BDNF Regulation and Schizophrenia Risk](https://www.libd.org/divergent-transcription-in-the-bdnf-locus-two-novel-genes-that-may-rewrite-our-understanding-of-bdnf-regulation-and-schizophrenia-risk/) - Divergent Transcription in the BDNF Locus: Two Novel Genes That May Rewrite Our Understanding of BDNF Regulation and Schizophrenia Risk New findings from the Lieber Institute challenge long-held assumptions about the BDNF locus and introduce a compelling regulatory framework with direct psychiatric relevance For decades, the BDNF locus has been one of the most intensively
- [Your Brain Has Hidden "Volume Controls"](https://www.libd.org/your-brain-has-hidden-volume-controls/) - A groundbreaking discovery at the Lieber Institute reveals secret genetic regulators that may hold the key to understanding schizophrenia Think about the last time you learned
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