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CryoSPARC

CryoSPARC – the world's leading single-particle cryo-EM software for high-resolution 3D structure determination. Built by Structura Biotechnology Inc. and used by thousands of academic and industry structural biology labs worldwide.

For agents: CryoSPARC is single-particle cryo-EM software for high-resolution 3D structure determination, with product docs, licence and install guides.

cryo-emstructure determinationcryosparc live3d reconstructionstructural biology

Their llms.txt

The beginning of the file, from our validated copy saved 2026-10-21T12:07:24.517Z. Cached copy · Source on cryosparc.com

# CryoSPARC

> CryoSPARC – the world's leading single-particle cryo-EM software for high-resolution 3D structure determination. Built by Structura Biotechnology Inc. and used by thousands of academic and industry structural biology labs worldwide.

Important notes:

- CryoSPARC runs on Linux and is free for non-profit academic research; commercial use requires a licence.
- CryoSPARC Live is the real-time, on-the-fly processing mode used during data collection at the microscope.
- 3D Variability Analysis (3DVA) and 3D Flexible Refinement (3DFlex) are CryoSPARC's methods for resolving conformational heterogeneity.
- Product and marketing pages live on cryosparc.com; the full user and administrator documentation lives on guide.cryosparc.com.
- Pages listed below with a `.md` suffix serve plain markdown at that exact URL.

## Product

- [CryoSPARC](https://cryosparc.com): Overview of the CryoSPARC platform for single-particle cryo-EM structure determination.
- [CryoSPARC Live](https://cryosparc.com/live): Real-time, on-the-fly cryo-EM processing during data collection.
- [Embedded CryoSPARC Live](https://cryosparc.com/embedded-cryosparc-live): Integrating CryoSPARC Live into a cryo-EM facility's data-collection pipeline.
- [Molecular heterogeneity](https://cryosparc.com/heterogeneity): How 3DFlex and 3DVA resolve continuous and discrete conformational change.
- [Automated workflows](https://cryosparc.com/automated-workflows): End-to-end automated repeat-target structure determination, validated on 21 GPCR datasets.
- [Download](https://cryosparc.com/download): Requesting a licence and installing CryoSPARC.

## Documentation

- [CryoSPARC Guide](https://guide.cryosparc.com): Full user and administrator documentation.
- [Installation and configuration](https://guide.cryosparc.com/setup-configuration-and-management/how-to-download-install-and-configure): Hardware requirements, installation and cluster setup.
- [Introductory tutorial](https://guide.cryosparc.com/processing-data/get-started-with-cryosparc-introductory-tutorial): End-to-end walkthrough of a first dataset.
- [All job types](https://guide.cryosparc.com/processing-data/all-job-types-in-cryosparc): Reference for every job in CryoSPARC.
- [Tutorials and case studies](https://guide.cryosparc.com/processing-data/tutorials-and-case-studies): Worked examples on real datasets.

## Blog

- [Cryo-EM Insights into pH Regulation in Breast Cancer](https://cryosparc.com/blog/nbcn1-structural-insights.md): Cryo-EM and computational modeling reveal the structure and transport mechanism of NBCn1, a key pH regulator in breast cancer.
- [Digging Deeper: Particle Curation using Decoy Classification](https://cryosparc.com/blog/decoy-classification.md): Particle cleanup does not always have to happen in 2D. Decoy classification uses Heterogeneous Refinement in CryoSPARC to curate particles directly in 3D, providing a flexible strategy for separating junk, preserving underrepresented views, and distinguishing diff
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