aperiondx.com valid
AperionDx
AperionDx Inc. develops protein diagnostic solutions built on Protein-PCR™, which runs
- Authority
- 46 reach 0 · trust 8 · quality 23 · freshness 15
- Tier
- listed
- llms.txt
- https://www.aperiondx.com/llms.txt
- llms-full.txt
- https://www.aperiondx.com/llms-full.txt
- Sections
- 9
- Links
- 5
- Size
- 3888 bytes
- Registered
- 2025-08-21
- Country
- United States Site-published organization address
- Publisher address country
- United States Site-published organization address; location is not independently verified
- Country evidence
- US · Site-published organization address 2026-10-27
- For agents
- Documentation: developer or product docs worth reading, nothing to call
- First seen
- 2026-10-26T15:40:14.333Z
- Last checked
- 2026-10-27T14:40:35.894Z
- Badge
Their llms.txt
The beginning of the file, from our validated copy saved 2026-10-26T15:40:14.339Z. Cached copy · Source on aperiondx.com
# AperionDx
> AperionDx Inc. develops protein diagnostic solutions built on Protein-PCR™, which runs
> on existing qPCR instruments — making protein detection more sensitive, more reliable,
> faster and effortlessly scalable with no new hardware.
Founded 2015. Based in Carlsbad, California, USA.
## What Protein-PCR is
Protein-PCR measures protein biomarkers using qPCR instruments laboratories already own,
creating a global protein-measurement network with minimal setup, no new hardware, and
easy rollout.
Key properties, as stated by AperionDx:
- **Ultimate sensitivity** — redefines the state-of-the-art sensitivity (LOD) for important
TBI and Alzheimer's disease protein biomarkers.
- **Accessible** — runs on widely available, generic qPCR systems; no expensive, proprietary
hardware required. Competitive platforms use proprietary instruments costing from
$70,000 to $600,000.
- **Comprehensive** — detects multiple key biomarkers in a single well via a cost-effective
workflow.
- **Clinically aligned** — designed to complement imaging and cerebrospinal fluid (CSF) assays.
- **Scalable** — high-throughput testing for research and clinical settings with a
1.5-4 hour turnaround time.
## Assay panels
Protein-PCR is unrestricted in the proteins it can detect, with very wide linear range
assays. These include tests for infectious disease and cardiac analytes as well as those
essential for detecting neurological diseases.
**Alzheimer's disease** — quantifies Aβ40, Aβ42, pTau181 and pTau217. 97.5% PPA/NPA or
greater versus Simoa®/ELISA. Supports the potential to identify risk 10+ years before the
appearance of clinical symptoms.
**Traumatic brain injury (TBI)** — quantifies GFAP, ALDOC, NGRN, BDNF and ST2. 97.5%
PPA/NPA or greater agreement with established methods. Supports early assessment, risk
stratification and ongoing monitoring.
**Split-sample comparison** — in split sample testing with an independent, experienced
laboratory, Protein-PCR performed in strong agreement with SIMOA for GFAP and BDNF
(R2 = 0.86 and 0.85 respectively), and better than the combination of SIMOA and ELISA:
PPA 100% (AD) and 97.7% (TBI); NPA 97.5% (AD) and 100% (TBI).
## Sample types
Standard blood samples. Serum and plasma have already been qualified; other sample types
may be used but have not yet been qualified.
## Workflow
1. **Detect** — measure full panels of disease-specific biomarkers from blood samples at
extremely low concentrations.
2. **Scale** — compatible with 96- and 384-well plates, processing up to 350 samples per plate.
3. **Deliver** — turnaround time (TAT) in 1.5-4 hours.
## Who it is for
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