Generated by Rank Math SEO, this is an llms.txt file designed to help LLMs better understand and index this website. # OHF ## Sitemaps - [XML Sitemap](https://ohf.org/sitemap_index.xml): Includes all crawlable and indexable pages. ## Posts - [Does Cooking Reduce Oxalates?​](https://ohf.org/blogs/does-cooking-reduce-oxalates/): Boiling and draining high-oxalate vegetables can meaningfully reduce the soluble oxalate they contain. Learn six simple preparation methods, which foods benefit most, and what cooking cannot do for people with primary hyperoxaluria. - [Why You Keep Getting Kidney Stones](https://ohf.org/blogs/why-do-i-keep-getting-kidney-stones-hyperoxaluria/): Kidney stones are common, but recurring stones may point to hyperoxaluria, a condition in which there is too much oxalate in the urine. Learn the three types, dietary, enteric, and primary, why identifying the type matters, and when to ask your provider about testing. - [Calcium & Oxalate: Understanding Their Role in Kidney Health](https://ohf.org/blogs/calcium-oxalate-understanding-their-role-in-kidney-health/): Learn how calcium & oxalate interact in the body, why dietary calcium may reduce oxalate absorption, and what it means for kidney stones and hyperoxaluria. - [Low-Oxalate Diet: The Complete Guide With Food Lists & Meal Plan](https://ohf.org/blogs/low-oxalate-diet/): A low-oxalate diet is a structured plan that limits foods containing high amounts of oxalic acid, a naturally occurring compound found in many plant-based foods ## Pages - [What is Hyperoxaluria?](https://ohf.org/resources/what-is-hyperoxaluria/): Hyperoxaluria is when your body produces or absorbs too much oxalate, a substance found in some foods and produced by your body. Usually, oxalate is filtered out through urine, but excess amounts can lead to problems. - [CHOP Webinar](https://ohf.org/chop-webinar/): ★ OHF × CHOP Care Center Webinar - [Social](https://ohf.org/social/): ★ OHF Connect - [Blog](https://ohf.org/blogs/): Your Impact Starts Here - [Find an OHF Care Center](https://ohf.org/ohf-care-centers/find-a-center/): OHF CARE CENTER NETWORK - [Home](https://ohf.org/): Your Global Home for Hyperoxaluria - [Detailed Workshop Agenda](https://ohf.org/international-hyperoxaluria-workshop-old/detailed-workshop-agenda/): DOWNLOAD IHW 2026 AGENDA IN .PDF IHW 2026 Workshop Schedule Start Name Affiliation Country Title Friday, 26 June 2026 8:00 AM Registration 8:45 AM Jakub Zieg, MD, PhD University Hospital Motol, Prague Czech Republic Welcome 8:50 AM Kyle Wood, MD & Yaacov Frishberg, MD University of Alabama, Birmingham & Shaare Zedek Medical Center United States & Israel Introduction 9:00 AM Peter C. Harris, PhD Mayo Clinic, Rochester United States Is There Further Genetic Heterogeneity in PH? Lessons from Polycystic Kidney Disease Session 1: From Metabolism to Disease: The Impact of OxalateChair: Todd Lowther, PhDWake Forest University School of MedicineUnited States 9:25 AM Ehud Ohana, PhD Ben Gurion University of the Negev Israel Altered Metabolic Homeostasis Rewires Hepato-Renal Axis Signaling in Primary Hyperoxaluria Type 3 9:40 AM Gerlineke Hawkins Van der Cingel, MBBS Charité – Universitätsmedizin Berlin Germany Effect of Lumasiran in Hyperoxalaemic Patients on Maintenance Haemodialysis 9:55 AM Kyle Wood, MD University of Alabama, Birmingham United States Mouse model of MASH Oral Abstract Speed Round: 10:10 AM Sonia Fargue, MD, PhD University of Alabama, Birmingham United States Metabolic Dysfunction-Associated Steatotic Liver Disease in a Mouse Model of Primary Hyperoxaluria Type 1 10:17 AM Megan Prochaska, MD, MPH University of Chicago Medicine, Chicago United States The Oxalate and Citrate Association in Humans 10:24 AM Coffee Break Session 2: From Bench to Bedside: PH2 and PH3Chair: Hadas Shasha-Lavsky, MDGalilee Medical CenterIsrael 10:45 AM Efrat Ben-Shalom, MD Shaare Zedek Medical Center Israel What Have We Learned Since the Discovery of PH3? 11:00 AM Nicola Brunetti-Pierri, MD University of Naples Italy Animal Models for PH3 11:15 AM Ruth Belostotsky, PhD Shaare Zedek Medical Center Israel Primary Hyperoxaluria Type 3 Metabolites: Are They Drivers of the Disease? 11:30 AM Tijn Rozemuller, MD, PhD Amsterdam University Medical Center The Netherlands Why Did Nedosiran Not Work in PH2/PH3? 11:45 AM Moderator: Michael Somers, MD Boston Children's Hospital United States Panel: All session speakers 12:00 PM Lunch Break Session 3: Where We Are Today: Treatment of Primary HyperoxaluriaChair: Mathieu Lemaire, MSc MDCM PhD FRCP(C)The Hospital for Sick Children TorontoCanada 1:00 PM David Sas, DO Mayo Clinic, Rochester United States Real World Use of siRNA 1:15 PM Mathieu Lemaire, MD MSc MDCM PhD FRCP(C) The Hospital for Sick Children Toronto Canada Move Over, Liver Kidney-Alone Transplantation Takes Center Stage for PH1 - Thanks to siRNA Therapy 1:30 PM Laila Oubram, MD Amsterdam University Medical Center Netherlands Optimizing Access to Lumasiran in Primary Hyperoxaluria Type 1 through a National Response-Guided Protocol 1:37 PM Kyle Wood, MD University of Alabama, Birmingham United States Medical vs. Surgical: Where Do New Therapies Change the Game? Oral Abstract Speed Round: 1:52 PM Hadas Shasha - Lavsky, MD Galilee Medical Center Israel Israel Lumasiran Treatment Outcomes in Infants with Primary Hyperoxaluria Type 1 1:59 PM Laila Oubram, MD Amsterdam University Medical Center Netherlands Pregnancy During Active Lumasiran Therapy in Primary Hyperoxaluria Type 1 2:06 PM Georgia Mandrile, MD, PhD AOU San Luigi Gonzaga Italy Functional and In Silico Characterization of Common AGXT Variants as Potential Modifiers of Primary Hyperoxaluria Type 1 2:13 PM Moderator: Michelle Baum, MD Boston Children's Hospital United States Panel: All session speakers 2:30 PM Coffee Break Session 4: Managing Stone Burden: Urological Perspectives in HyperoxaluriaChair(s): Thomas Chi, MD, MBA, FACS & Zham Okhunov, M.D.The University of Alabama, Birmingham & University of UtahUnited States 3:00 PM Tom Chi, MD, MBA, FACS University of Alabama, Birmingham United States Bridging the Gap: Urologys Role in Early Detection of Hyperoxaluria 3:15 PM Kevin Koo, MD Mayo Clinic, Rochester United States What Are Endourologists Thinking? The Surgical Perspective on Complex Stones 3:30 PM Chen-Han Wilfred Wu, MD, PhD University of Alabama Birmingham United States The Perspective of a Geneticist: Rare Stone Disease Oral Abstract Speed Round: 3:45 PM Mazzy Marcucci, BS University of Utah United States Data-Driven Metabolic Phenotyping of Calcium Oxalate Nephrolithiasis Using Model-Based Clustering 3:52 PM Qazi Saqib Hamid, MD Aga Khan University Pakistan Contribution of Primary Hyperoxaluria in a High-Risk Pakistani Cohort: Genetic and Phenotypic Insights 3:59 PM Moderator(s): Kyle Wood, MD University of Alabama Medicine, Birmingham United States Audience Polling & Panelists: All session speakers 4:15 PM Kyle Wood, MD University of Alabama Medicine, Birmingham United States Day 1 Closing 4:20 PM Welcome Reception / Poster Session 5:20 PM FINISH Saturday, 27 June 2026 8:00 AM Registration & Poster Viewing 8:45 AM Kim Hollander Oxalosis and Hyperoxaluria Foundation United States Day 2 Welcome Session 5: Enteric Hyperoxaluria: What’s Next in Care and TreatmentChair(s): Jonathan Whittamore, PhD & Dirk Lange, PhDUT Southwestern Medical Center & University of British ColumbiaUnited States & Canada 8:50 AM Elaine Worcester, MD University of Chicago Medicine United States Outcomes of Enteric Hyperoxaluria – Stone and CKD Risk 9:05 AM John Knight, PhD University of Alabama, Birmingham United States Enteric Hyperoxaluria: The Role of Oxalobacter Formigenes or Other Genetically Modified Bacteria 9:20 AM Lama Nazzal, MD NYU Langone Health United States Targeting the Oxalobiome: Therapeutic Opportunities and Translational Challenges 9:35 AM Abraham Matar, MD Dartmouth Geisel School of Medicine United States From Bariatric Surgery to Enteric Hyperoxaluria and Kidney Transplantation 9:50 AM John Lieske, MD Mayo Clinic, Rochester United States What Happened to Enteric Hyperoxaluria Therapies? 10:05 AM Coffee Break Session 6: Pipeline and Progress: Emerging Therapies in Primary HyperoxaluriaChair(s): Sonia Fargue, MD, PhD & Monica Diaz Gavilan, PhDUniversity of Alabama, Birmingham & University of GranadaUnited States & Spain 10:30 AM Monica Diaz Gavilan, PhD University of Granada Spain Small Molecules– Targeting Protein Degradation in PH1 10:45 AM Barbara Cellini, PhD University of Perugia Italy Misfolding-Corrective Approaches in the Therapy of PH1 11:00 AM Mervi E. Hyvönen, MD, PhD Helsinki University Hospital and University of Helsinki Finland Gene Editing as a Therapeutic Strategy for Hyperoxaluria 11:15 AM Michelle Logsdon Gauvin, PhD Stanford University United States Potential for mRNA Therapeutics in Primary Hyperoxaluria 11:30 AM Emmanuel Letavernier, MD, PhD Tenun Hospital France Stiripentol: Set-up of the CRYSTAL Study 11:40 AM Marc De Broe, MD, PhD Antwerp University Hospital Belgium The Role of the Gut for PH Treatment 11:55 AM John Lieske, MD Mayo Clinic, Rochester United States redePHine: Advancing Gene Editing for Primary Hyperoxaluria Type 1 12:05 PM Matthew Breeggemann, MD University of California San Francisco United States YOLT-203, an In Vivo Gene-Editing Therapy for Primary Hyperoxaluria Type 1: Interim Results from Two Investigator-Initiated Trials Oral Abstract Speed Round: 12:15 PM Todd Lowther, PhD Wake Forest University School of Medicine United States Inhibition of Hydroxyproline Dehydrogenase as a Therapy for Primary Hyperoxaluria 12:22 PM Lisa Ellerby, PhD The Buck Institute United States N-Propargylglycine Restores Survival by Preventing Calcium Oxalate Stone Formation, Tubular Injury, and Kidney Dysfunction in a Lethal Mouse Model of Primary Hyperoxaluria Type 2 12:30 PM Lunch Break Session 7: From Data to Care: Registries & Centers of ExcellenceChair: Shabbir Moochhala, MD, PhD, FRCPERoyal Free HospitalUnited Kingdom 1:30 PM Kim Hollander, Executive Director The Oxalosis and Hyperoxaluria Foundation United States Advancing Hyperoxaluria Through Global Collaboration Subtitle: Partnering with Patients, Clinicians, Researchers, and Advocates Worldwide 1:40 PM Bhaskar Somani, MD University Hospital Southampton NHS Trust United Kingdom How to Create a Multidisciplinary Stone Teams 1:55 PM Matthew Breeggemann, MD University of California San Francisco United States OHF Care Center Network: Advancing Global Care Together 2:10 PM Shabbir Moochhala, MD, PhD, FRCPE & John Lieske, MD Royal Free Hospital & Mayo Clinic, Rochester United States & United Kingdom PH Registries: Collaboration in Action Living with Hyperoxaluria: Global Patient and Caregiver Perspectives on Care, Access, and TreatmentModerator: Kevin Koo, MDMayo ClinicUnited States 2:25 PM Luigi (Italy) - Italian Hyperoxaluria Association Kristi (United States) - Finding A Way Maarten (the Netherlands) Zain (United Kingdom) Irene (Poland) - PH-Europe 2:50 PM Coffee Break Session 8: Global Perspectives in PH: Insights from Around the WorldChair(s): Mini Michael, MD & Yaacov Frishberg, MD 3:20 PM Velibor Tasic, MD, PhD, FESPN University Children's Hospital Macedonia 3:27 PM Eva Flachsova, MD, PhD Charles University Czech Republic 3:34 PM Naveen Soliman, MD Cairo University Egypt 3:41 PM Faïza Meiouet, PhD Royal Gendarmerie Medical Research and Analysis Laboratory Morocco 3:48 PM Marta Monteverde, MD Hospital de Pediatría JP Garrahan Argentina 3:55 PM Maria Helena Vaisbich, MD, PhD University of São Paulo School of Medicine – Clinics Hospital Brazil 4:02 PM Aditi Sinha, MD, PhD All India Institute of Medical Sciences India 4:09 PM Seema Hashmi, MD Sindh Institute of Urology and Transplantation Pakistan 4:16 PM Moderator(s): Mini Michael, MD & Yaacov Frishberg, MD Texas Children's Hospital & Shaare Zedek Medical Center United States & Israel Panel: All Speakers 4:30 PM Kyle Wood, MD and Yaacov Frishberg, MD University of Alabama, Birmingham & Shaare Zedek Medical Center United States & Israel Closing 4:35 PM FINISH 7:00 PM Trolley Transfer to Farewell Dinner Farewell Dinner - [Oral Presentation Guidelines](https://ohf.org/international-hyperoxaluria-workshop-old/oral-presentation-guidelines/): All oral presentations must be accompanied by a PowerPoint presentation. Presenters are fully responsible for the presentation content (including order, graphics, etc.).   Please prepare your presentation using the latest version of Microsoft PowerPoint (but older versions are also supported). The screen aspect ratio will be 16:9. Please avoid using Apple Keynote and Prezi presentations, as the on-site computers will support PowerPoint format only. Mac users can export their files to PowerPoint by selecting "Export to > PowerPoint". Please ensure that your presentation is saved in a compatible format, as indicated below. - [Poster Guidelines](https://ohf.org/international-hyperoxaluria-workshop-old/poster-guidelines/): All poster presenting authors are asked to bring their printed posters to the venue. Alternatively, poster authors can order a printing service in Prague arranged by our Secretariat. - [Social Programme](https://ohf.org/international-hyperoxaluria-workshop-old/social-programme/): Join us for the OHF Farewell Dinner on 27 June at Mlýnec Restaurant, an elegant riverside venue located beside the iconic Charles Bridge, offering a refined setting in the heart of Prague. - [Contact Us](https://ohf.org/international-hyperoxaluria-workshop-old/contact-us/): Contacts REGISTRATION For inquiries about the registration: registration.ihw2026@c-in.eu REGISTRATION For inquiries about the registration: registration.ihw2026@c-in.eu PROGRAM For inquiries about the program: abstracts.ihw2026@c-in.eu - [Travel Grants](https://ohf.org/international-hyperoxaluria-workshop-old/travel-grants/): A limited number of travel grants will be available to selected young investigators whose abstracts are accepted for oral or poster presentation. The total amount allocated for these travel grants is USD 16,000, which will be distributed among the selected participants. - [Accommodation](https://ohf.org/international-hyperoxaluria-workshop-old/accommodation/): Address: - [Venue](https://ohf.org/international-hyperoxaluria-workshop-old/venue/): Address: Svobodova 1128 00 Prague 2Czech Republic - [Destination](https://ohf.org/international-hyperoxaluria-workshop-old/destination/): Currency: Czech Crown (CZK) Language: Czech (English is widely spoken in hotels, restaurants, and tourist areas) Time Zone: Central European Time (CET)  - [Abstract Submission Guidelines](https://ohf.org/international-hyperoxaluria-workshop-old/abstract-submission-guidelines/): The abstract submission closed on 16 April 2026. If you are interested in submitting a late abstract, please contact us at julieb@ohf.org. - [Registration Guidelines](https://ohf.org/international-hyperoxaluria-workshop-old/registration-guidelines/): ·         Register via the Online Services Portal using a new or existing account (you may already have one from the IPNA Congress).  - [Share Your Story](https://ohf.org/share-your-story-3/): Tiffany was diagnosed with primary hyperoxaluria as an adult after years of unexplained kidney stones. In this short film, she shares what the day of her diagnosis felt like, how her family rallied around her, and why she chose to step forward as an advocate for the OHF community. - [In Rare We Care](https://ohf.org/share-your-story-2/): Joining us in this year’s activity around the In Rare We Care theme is a chance to show the strength of our united community and raise awareness of hyperoxaluria around the world. The goal is simple: to share hope, show unity, and let families everywhere knowthey are not alone. - [OHF Care Center Network Application](https://ohf.org/ohf-care-center-network-application/): Please review all requirements, instructions, and criteria stipulated in the OHF Care Center Network Standards for Certification available here.  - [OHF Care Center Standards of Care](https://ohf.org/ohf-care-centers/network-guidelines/): Please review OHF Care Center Network Standards for Certification available here.  - [OHF Care Center Network](https://ohf.org/ohf-care-centers/): Everyone living with hyperoxaluria deserves the best care and support. The OHF Care Center Network is where dedicated experts work together to diagnose and treat hyperoxaluria. These centers share knowledge and best practices to improve care and research, collectively addressing the most significant challenges in hyperoxaluria. Together, our Centers are determined to meet the greatest medical challenges and unmet needs of the hyperoxaluria patient community.  - [Launching the OHF Care Center Network](https://ohf.org/ohf-care-center-network/): We need 200 building blocks to help create the OHF Care Center Network. - [Oxalate Food Content Database](https://ohf.org/oxalate-food-content-database/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you.  - [Fruit Oxalate](https://ohf.org/fruit-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Vegetables Oxalate](https://ohf.org/vegetables-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Grain Oxalate](https://ohf.org/grain-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Protein Oxalate](https://ohf.org/protein-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Dairy Oxalate](https://ohf.org/dairy-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Fats Oxalate](https://ohf.org/fats-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Beverages Oxalate](https://ohf.org/beverages-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Sweets Oxalate](https://ohf.org/sweets-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Spices Oxalate](https://ohf.org/spices-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Commercial Oxalate](https://ohf.org/commercial-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [Supplements Oxalate](https://ohf.org/supplements-oxalate/): The OHF has worked with dietary experts, and experts in hyperoxaluria care and research to develop a resource for oxalate levels in many common foods and beverages. It is important to note that we are all different. Managing diet for enteric hyperoxaluria, adding or removing certain foods, sometimes known as nutrition therapy, should be discussed individually with your providers who take your unique characteristics, needs, likes, and dislikes into consideration when planning the best diet for you. - [PH1 of a Kind](https://ohf.org/ph1-of-a-kind/): https://youtu.be/TrhfC3FijBM - [Grants Funded Archive](https://ohf.org/grants-funded-archive/): The Oxalosis and Hyperoxaluria Foundation (OHF) is proud to be the largest nonprofit provider of grants for hyperoxaluria research in the world. Since our founding, The OHF has raised and committed more than $40 million for hyperoxaluria research, and has funded over 60 grants. Learn more about our early grants here and visit our Grants & Funding page for more information. - [2025 In-Person Meeting Travel Grants](https://ohf.org/2025-in-person-meeting-travel-grants/): Advocate Support is available to domestic or international patients, close family and friends, and advocates in the hyperoxaluria community.    - [2023 In-Person Meeting Registration](https://ohf.org/2023-in-person-meeting-registration/) - [Patient and Family Summit 2025](https://ohf.org/meeting_2025/): Nashville, TN - [Beth’s Story](https://ohf.org/life-is-beautiful/life-is-beautiful-beths-story/): My name is Beth, and I was diagnosed with PH1 twenty years ago, along with my brothers Steve and Eric. Sadly, we lost Steve in 2003 and Eric in 2017 as the result of the ravages of PH1. I am writing to ask you, along with other patients, caregivers, friends, and loved ones, to join me in the OHF’s “Life Is Beautiful” campaign to celebrate that our lives, and the lives of those we love and care for, are in fact beautiful and joyful despite the fear and pain wrought by primary hyperoxaluria. That is the essence of why we fight— because everyday that our community digs in together and makes progress against this disease, somewhere a life is extended or made fuller— and that is beautiful. - [Life is Beautiful](https://ohf.org/life-is-beautiful/): This summer, the OHF is collaborating with Beth and her family, members of the hyperoxaluria community who have motivated us to launch the Life is Beautiful campaign. Read Beth’s journey here, to gain a deeper understanding of the beautiful lives that motivated this initiative. - [Primary Hyperoxaluria](https://ohf.org/primary-hyperoxaluria/): PH is a family of rare, genetic disorders that affect the body's ability to regulate the production of oxalate which can result in kidney damage. The liver normally makes proteins, called enzymes, that prevent the body from making too much oxalate. In PH, the liver doesn’t create enough of this enzyme, or the enzyme doesn’t work properly. To date, experts have identified three different genetic causes of PH. - [Enteric Hyperoxaluria](https://ohf.org/enteric/):