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# Lifespan Research Institute

Building a Future Free of Age-Related Disease

## Sitemaps

- [XML Sitemap](https://www.lifespan.io/sitemap.xml): Contains all public & indexable URLs for this website.

## Posts

- [How Multivitamins and Minerals Impact Health and Longevity](https://www.lifespan.io/news/how-multivitamins-and-minerals-impact-health-and-longevity/) - A recent review evaluated studies with 5.5 million participants to assess the impact of multivitamin and mineral supplements on different aspects of health.
- [Researchers Find a Potential Target for Hearing Loss](https://www.lifespan.io/news/researchers-find-a-potential-target-for-hearing-loss/) - In Aging Cell, researchers have identified bone marrow stromal antigen 2 (BST2) as a key protein in age-related hearing loss in a mouse model.
- [Bacterium From Frogs Completely Destroys Colon Cancer](https://www.lifespan.io/news/bacterium-from-frogs-completely-destroys-colon-cancer/) - Multiple strains of bacteria taken from frogs, newts, and lizards can be effective against human colon cancer in a mouse model.
- [Producing Thymic Factors in the Liver Rejuvenates Immunity](https://www.lifespan.io/news/producing-thymic-factors-in-the-liver-rejuvenates-immunity/) - A novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function.
- [Maximina Yun on the Wonders of the Axolotl](https://www.lifespan.io/news/maximina-yun-on-the-wonders-of-the-axolotl/) - Dr. Maximina Yun, principal investigator at Chinese Institutes for Medical Research in Beijing, studies some of the most amazing animals: salamanders.
- [Aging: Why Does Evolution Kill?](https://www.lifespan.io/news/aging-why-does-evolution-kill/) - Why do we age at all, and why do different species age at such dramatically different rates? Biologists still disagree on the most basic questions.
- [A Gene That Changes Function With Aging in Mice](https://www.lifespan.io/news/a-gene-that-changes-function-with-aging-in-mice/) - Researchers have discovered how GDF3, a cytokine that increases with aging, is related to increased inflammatory macrophages in older animals.
- [Human Umbilical Cord Blood Metabolites Lengthen Worms' Lives](https://www.lifespan.io/news/human-umbilical-cord-blood-metabolites-lengthen-worms-lives/) - Two different formulas, each a mix of a few metabolites, demonstrated anti-senescence properties in cell cultures and model organisms.
- [Analyzing the Quality of Preclinical Anti-Aging Research](https://www.lifespan.io/news/analyzing-the-quality-of-preclinical-anti-aging-research/) - Researchers have analyzed how study quality changed over time, shortcomings in research, and the improvements that can be made in the future.
- [Senescence Exacerbated by Mitochondrial RNA Leakage](https://www.lifespan.io/news/senescence-exacerbated-by-mitochondrial-rna-leakage/) - Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm.
- [Targeting a Metabolic Regulator Reduces Fat in Mice](https://www.lifespan.io/news/targeting-a-metabolic-regulator-reduces-fat-in-mice/) - In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47.
- [A Year of Rejuvenation Research and Journalism](https://www.lifespan.io/news/a-year-of-rejuvenation-research-and-journalism/) - It is a time for cozy nights by the fire and a great time to catch up on what has been happening at Lifespan News and LRI.
- [Molecule From Chocolate Linked to Slower Epigenetic Aging](https://www.lifespan.io/news/molecule-from-chocolate-linked-to-slower-epigenetic-aging/) - A new observational study spanning two human cohorts has found a link between theobromine, a phytochemical abundant in cocoa, and slower epigenetic aging [1].
- [A Key Molecular Link Between Aging and Osteoporosis](https://www.lifespan.io/news/a-key-molecular-link-between-aging-and-osteoporosis/) - Age-related deficiency in another compound leads an antioxidant to contribute to bone deterioration in osteoporosis by siphoning from a bone-building pathway.
- [Stem Cell-Derived Vesicles Improve Cognition in Aged Monkeys](https://www.lifespan.io/news/stem-cell-derived-vesicles-improve-cognition-in-aged-monkeys/) - Extracellular vesicles derived from mesenchymal stem cells improved spatial working memory in macaques, suggesting a possible reversal of cognitive decline.
- [Nasal Tissue Extracellular Vesicles Improve Health in Mice](https://www.lifespan.io/news/nasal-tissue-extracellular-vesicles-improve-health-in-mice/) - Extracellular vesicles derived from the nasal mucosa provide significant regenerative benefits to tissues throughout the body, including the brain.
- [2nd Hevolution Global Healthspan Report Calls for Action](https://www.lifespan.io/news/2nd-hevolution-global-healthspan-report-calls-for-action/) - Hevolution Foundation highlights that extending the number of years people live in good health is a defining challenge for economies and societies worldwide.
- [Microglia Replacement Already Working in Humans](https://www.lifespan.io/news/microglia-replacement-already-working-in-humans/) - Microglia replacement is a strategy that made the leap from mouse studies to the first successful human trial in just five years.
- [Insilico Medicine Presents AI-Empowered Dual-Action PROTAC](https://www.lifespan.io/news/insilico-medicine-presents-ai-empowered-dual-action-protac/) - PKMYT1 (Membrane-associated Tyrosine/Threonine Protein Kinase 1) is a serine/threonine protein kinase that plays a pivotal role in cell cycle regulation.
- [Engineering Immune Cells to Fight Gut Senescence](https://www.lifespan.io/news/engineering-immune-cells-to-fight-gut-senescence/) - Targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice.
- [Second-Hand Smoke Alters Protein Expression](https://www.lifespan.io/news/second-hand-smoke-alters-protein-expression/) - A recent study investigated plasma proteins in people exposed to secondhand smoke and found that exposure affected multiple molecular processes.
- [Arginine Reduces Signs of Alzheimer’s in Mice](https://www.lifespan.io/news/arginine-reduces-signs-of-alzheimers-in-mice/) - In a new study, the amino acid arginine shows promise in animal models of amyloid aggregation due to its ability to promote protein folding.
- [Rejuvenation Roundup November 2025](https://www.lifespan.io/news/rejuvenation-roundup-november-2025/) - U.S. researchers have finished eating turkey and begun shopping, but their work continues. Here's what people have been doing to fight aging in November.
- [A Subtype of T Cells Counters Senescence in Mice](https://www.lifespan.io/news/a-subtype-of-t-cells-counters-senescence-in-mice/) - Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence.
- [An AI-Based System Has Found a Potential Longevity Drug](https://www.lifespan.io/news/an-ai-based-system-has-found-a-potential-longevity-drug/) - Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions.
- [The Roles of Phenylalanine and Tyrosine in Lifespan](https://www.lifespan.io/news/the-roles-of-phenylalanine-and-tyrosine-in-lifespan/) - A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data.
- [Fixing Lysosomes Improves Blood Stem Cell Function](https://www.lifespan.io/news/fixing-lysosomes-improves-blood-stem-cell-function/) - Lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments.
- [Nanoparticles Improve Intercellular Mitochondrial Transfer](https://www.lifespan.io/news/nanoparticles-improve-intercellular-mitochondrial-transfer/) - Nanoflowers nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function.
- [George Church on Building “Scientific Superintelligence”](https://www.lifespan.io/news/george-church-on-building-scientific-superintelligence/) - One company has been seeing an unusual amount of George Church's attention: Lila Sciences, where he assumed the role of Chief Scientist.
- [How Senescent Cells Encourage Melanoma Growth](https://www.lifespan.io/news/how-senescent-cells-encourage-melanoma-growth/) - Researchers publishing in Aging Cell have documented one key reason why older people are much more likely to get melanoma.
- [The Impact of Plant Polyphenols on Ovarian Aging](https://www.lifespan.io/news/the-impact-of-plant-polyphenols-on-ovarian-aging/) - A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging.
- [Vincere Biosciences Awarded $5 Million Grant](https://www.lifespan.io/news/vincere-biosciences-awarded-5-million/) - Vincere Biosciences today announced the receipt of a $5 million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF).
- [Improved Stem Cells Rejuvenate the Brains of Monkeys](https://www.lifespan.io/news/improved-stem-cells-rejuvenate-the-brains-of-monkeys/) - Human mesenchymal progenitor cells that express a more potent version of FOXO3 produce rejuvenative effects in monkeys, mice, and human cells.
- [A Sarcopenia-Related MicroRNA May Help Pinpoint Its Origin](https://www.lifespan.io/news/a-sarcopenia-related-microrna-may-help-pinpoint-its-origin/) - In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle.
- [NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing](https://www.lifespan.io/news/nad-rescues-mouse-tauopathy-by-fixing-alternative-splicing/) - A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer's.
- [The Key Questions of Longevity Research](https://www.lifespan.io/news/the-key-questions-of-longevity-research/) - In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field.
- [If Death Were Optional, Would You Still Choose It?](https://www.lifespan.io/news/if-death-were-optional-would-you-still-choose-it/) - A recent questionnaire from YouGovChat included the question “If you could live forever, staying healthy and young, would you do it?”
- [Multilingualism Is Associated With Delayed Aging](https://www.lifespan.io/news/multilingualism-is-associated-with-delayed-aging/) - A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging.
- [New Gene Therapy Robustly Lowers LDL and Triglycerides](https://www.lifespan.io/news/new-gene-therapy-robustly-lowers-ldl-and-triglycerides/) - A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation.
- [High-Fiber Foods May Fight T Cell Senescence](https://www.lifespan.io/news/high-fiber-foods-may-fight-t-cell-senescence/) - Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells.
- [Mice With Reduced Astrocytic Oxidative Stress Live Longer](https://www.lifespan.io/news/mice-with-reduced-astrocytic-oxidative-stress-live-longer/) - Reducing the production of reactive oxygen species in astrocytes improves neuronal health and significantly increases lifespan in a mouse model of Alzheimer’s.
- [Insilico Unveils Portfolio of Unique Cardiometabolic Assets](https://www.lifespan.io/news/insilico-unveils-portfolio-of-unique-cardiometabolic-assets/) - Insilico Medicine announced the launch of its cardiometabolic disease portfolio of unique highly-differentiated molecules discovered using generative AI.
- [EDA2R May Be an Aging Biomarker and Inflammaging Target](https://www.lifespan.io/news/eda2r-may-be-an-aging-biomarker-and-inflammaging-target/) - A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways.
- [Rapamycin May Delay Age-Related Fertility Decline](https://www.lifespan.io/news/rapamycin-may-delay-age-related-fertility-decline/) - An increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility.
- [Sam Sharifi on Fixing Our DNA](https://www.lifespan.io/news/sam-sharifi-on-fixing-our-dna/) - I talked to Sam Sharifi, PhD, Matter Bio’s Chief Scientific Officer, about the company’s philosophy, technology, and research programs, and glimpsed the future.
- [Joe Betts-Lacroix on Retro Bio and Its Recent AI Advancement](https://www.lifespan.io/news/joe-betts-lacroix-on-retro-bio-and-its-recent-ai-advancement/) - Using an AI model based on GPT architecture, Retro scientists were able to tweak reprogramming factors, greatly improving reprogramming efficiency.
- [Andrea Maier on Longevity Medicine for All](https://www.lifespan.io/news/andrea-maier-on-longevity-medicine-for-all/) - Dr. Andrea Maier of the National University of Singapore is a veteran geroscientist and one of the most familiar faces in longevity medicine.
- [Skin Aging Underlined by Loss of Capillary Macrophages](https://www.lifespan.io/news/skin-aging-underlined-by-loss-of-capillary-macrophages/) - A new study has tied the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin.
- [Gabriel Cian on Investment and the 2060 Longevity Forum](https://www.lifespan.io/news/gabriel-cian-on-investment-and-the-2060-longevity-forum/) - In this Lifespan interview, we speak with Gabriel Cian, founder of the 2060 Longevity Forum, about how his background in software shaped his views.
- [Rejuvenation Roundup October 2025](https://www.lifespan.io/news/rejuvenation-roundup-october-2025/) - The trick-or-treaters have all gone home as the leaves have fallen to the ground, but rejuvenation biotech attempts to prevent human beings from fading away.
- [Men Might Need More Exercise to Lower Cardiovascular Risks](https://www.lifespan.io/news/men-might-need-more-exercise-to-lower-cardiovascular-risks/) - Men may need more than twice as much exercise as women do to achieve the same level of reduction in the risk of cardiovascular heart disease.
- [Maintenance Stays Efficient in Healthy Older People's Cells](https://www.lifespan.io/news/maintenance-stays-efficient-in-healthy-older-peoples-cells/) - The efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people.
- [Organ Fat Is Associated With Carotid Atherosclerosis](https://www.lifespan.io/news/organ-fat-is-associated-with-carotid-atherosclerosis/) - A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis.
- [Review Links Lingering Infections to Senescence](https://www.lifespan.io/news/review-links-lingering-infections-to-senescence/) - In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging.
- [Stiff Collagen May Lead to Senescent Cells](https://www.lifespan.io/news/stiff-collagen-may-lead-to-senescent-cells/) - A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence.
- [Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice](https://www.lifespan.io/news/amyloid-fibrinogen-complexes-exacerbate-alzheimers-in-mice/) - A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone.
- [The Global Conference on Gerophysics](https://www.lifespan.io/news/the-global-conference-on-gerophysics/) - This conference brings together leading theoretical physicists and eminent researchers in ageing and rejuvenation biology to explore gerophysics.
- [LongX Hosts the Youth in Longevity Biotech Showcase](https://www.lifespan.io/news/longx-hosts-the-youth-in-longevity-biotech-showcase/) - Longevity Xplorer will be hosting the first-ever "Youth in Longevity Biotech Showcase", a virtual event featuring lightning talks from young professionals.
- [Longevity Manhattan Project Launches: San Francisco, June 20](https://www.lifespan.io/news/longevity-manhattan-project-launches-san-francisco-june-20/) - Viva.city and BerlinHouse are opening Viva Frontier Tower, a 6-week popup village in the newly purchased 16-floor Frontier Tower in downtown San Francisco.
- [How Life Expectancy Has Changed in Europe](https://www.lifespan.io/news/how-life-expectancy-has-changed-in-europe/) - A recent country-level analysis of life expectancy among several European nations shows changes in life expectancy trends and offers policy recommendations.
- [Immortal Dragons Launches $40M Longevity Fund](https://www.lifespan.io/news/immortal-dragons-launches-40m-longevity-fund/) - Immortal Dragons, a purpose-driven longevity fund headquartered in Singapore, announced its unique approach to investing in radical life extension technologies.
- [Measuring Dog Aging With Protein Metabolism](https://www.lifespan.io/news/measuring-dog-aging-with-protein-metabolism/) - Dog Aging Project data have revealed that amino acids generated from protein metabolism, are useful in determining the biological ages of dogs.
- [Event Announcement: Longevity Science Summit](https://www.lifespan.io/news/event-announcement-longevity-science-summit/) - The Longevity Science Foundation (LSF) is thrilled to announce that it is organizing the Longevity Science Summit in Miami.
- [Founders Longevity Forum and NUS Announce Event](https://www.lifespan.io/news/founders-longevity-forum-and-nus-announce-event/) - Founders Longevity Forum Singapore is set to host a pivotal two-day event on 27-28 February 2025 in Singapore.
- [Longevity Investment More Than Doubled to $8.5bn in 2024](https://www.lifespan.io/news/longevity-investment-more-than-doubled-to-8-5bn-in-2024/) - Industry analysts at Longevity.Technology published the 2024 Annual Longevity Investment Report. Total financing reached USD $8.49 billion across 331 deals.
- [Researchers Find Age-Modulatory Perturbations at Scale](https://www.lifespan.io/news/researchers-find-age-modulatory-perturbations-at-scale/) - Scientists have developed a new open source transcriptomic aging clock and published their work as a pre-print. This could be used for regenerative medicine.
- [Addressing Age-Related Vision Decline With Lipid Supplements](https://www.lifespan.io/news/addressing-age-related-vision-decline-with-lipid-supplements/) - Researchers have partially reversed age-related vision decline in mice by injecting specific lipids directly into the retina.
- [The Aging Code Summit](https://www.lifespan.io/news/the-aging-code-summit/) - Longevity Global, Mindvyne, and 3cubed.ai announced that they will be partnering to co-host the Aging Code Summit and Pitch Fest, a two-day event.
- [NUS Medicine Launches New Clinical Trial Centre](https://www.lifespan.io/news/nus-medicine-launches-new-clinical-trial-centre/) - The Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) launched the Clinical Trial Centre under its Academy for Healthy Longevity.
- [Grant Award Announcement: Rejuvenating the Aging Brain Study](https://www.lifespan.io/news/grant-award-announcement-rejuvenating-the-aging-brain-study/) - The Longevity Science Foundation (LSF) is proud to announce a grant award to the University of Copenhagen’s Center for Healthy Aging.
- [Tiny Brain Organoids Show Promise in Alzheimer’s Research](https://www.lifespan.io/news/tiny-brain-organoids-show-promise-in-alzheimers-research/) - A novel multicellular integrated brain model to study neurological diseases incorporates all six major brain cell types derived from patient-specific iPSCs.
- [How Being in Orbit Affects Stem Cells](https://www.lifespan.io/news/how-being-in-orbit-affects-stem-cells/) - Researchers have published a review discussing what experiments conducted in space can do for stem cell research and medical research as a whole.
- [Female-Specific Mechanism of Neurodegeneration Discovered](https://www.lifespan.io/news/female-specific-mechanism-of-neurodegeneration-discovered/) - A gene on the X chromosome promotes inflammation and neurodegeneration in a mouse model of multiple sclerosis but is reversed with metformin.
- [Longevity Investor Network 2024 End of Year Update](https://www.lifespan.io/news/longevity-investor-network-2024-end-of-year-update/) - LRI created the Longevity Investor Network (LIN) to connect promising longevity tech companies with investors to get rejuvenation biotechnology to the clinic.
- [Infrared Lasers Clear Harmful Compounds in Mouse Brains](https://www.lifespan.io/news/infrared-lasers-clear-harmful-compounds-in-mouse-brains/) - Researchers have found that infrared lasers promote the clearance of toxic metabolites from the brains of age-accelerated mice by improving lymphatic drainage.
- [BioAge Labs: First Person Dosed in Phase 1 BGE-102 Trial](https://www.lifespan.io/news/bioage-labs-first-person-dosed-in-phase-1-bge-102-trial/) - BioAge Labs, Inc. today announced that the first participant has been dosed in a Phase 1 clinical trial evaluating BGE-102.
- [Boyang Wang on Targeting Underfunded Longevity Projects](https://www.lifespan.io/news/boyang-wang-on-targeting-underfunded-longevity-projects/) - In today's interview, Boyang Yang of Immortal Dragons discusses the kinds of projects he wants to fund and what got him involved in longevity.
- [Madrid Set to Become the Longevity Capital of Europe](https://www.lifespan.io/news/madrid-set-to-become-the-longevity-capital-of-europe/) - We are thrilled to announce the second edition of the International Longevity Summit in beautiful Madrid after the major success in 2024.
- [Chugai and Gero Enter Into Research and License Agreement](https://www.lifespan.io/news/chugai-and-gero-enter-into-research-and-license-agreement/) - Chugai Pharmaceutical Co., Ltd. and Gero PTE. LTD. announced a joint research and license agreement to develop novel therapies for age-related diseases.
- [Interventions Testing Program Finds Three New Compounds](https://www.lifespan.io/news/interventions-testing-program-finds-three-new-compounds/) - A new report from the Interventions Testing Program adds three new compounds to its list: epicatechin, halofuginone, and mitoglitazone.
- [Augmentation Lab Announces the Human Augmentation Summit](https://www.lifespan.io/news/augmentation-lab-announces-the-human-augmentation-summit/) - Join us on August 23, 2025, at the MIT Media Lab in Cambridge, MA, for a full-day summit exploring the frontiers of human potential and longevity.
- [2025 Asian Pacific Longevity Medicine International Summit](https://www.lifespan.io/news/2025-asian-pacific-longevity-medicine-international-summit/) - On October 4–5, 2025, the Asia-Pacific Longevity Society will host the inaugural Asian Pacific Longevity Medicine International Summit (APAC-LMIS) in Hong Kong.
- [Why Naked Mole Rats Have Better DNA Repair](https://www.lifespan.io/news/why-naked-mole-rats-have-better-dna-repair/) - Scientists have found that the protein cGAS in naked mole rats, a famously long-lived species, boosts DNA repair, while the human version tends to hamper it.
- [Researchers Identify Key Age-Related Genes](https://www.lifespan.io/news/researchers-identify-key-age-related-genes/) - In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging.
- [Rejuve.AI Launches App for Longevity Advice and Treatments](https://www.lifespan.io/news/rejuve-ai-launches-app-for-longevity-advice-and-treatments/) - Rejuve.AI launches Rejuve Longevity, which combines AI, cutting-edge research and blockchain technology to widen access to longevity treatments and advice.
- [Nanoparticles Potently Reverse Alzheimer’s in Mice](https://www.lifespan.io/news/nanoparticles-potently-reverse-alzheimers-in-mice/) - Scientists have created polymersome nanoparticles that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route.
- [A Public Website for Evaluating Potential Anti-Aging Drugs](https://www.lifespan.io/news/a-public-website-for-evaluating-potential-anti-aging-drugs/) - Researchers have showcased their creation of PASS GERO, a public-facing application that allows researchers to evaluate potential anti-aging compounds.
- [Meet ALSAE: Improving the Cultural Image of Longevity](https://www.lifespan.io/news/meet-alsae-improving-the-cultural-image-of-longevity/) - To challenge cultural stereotypes and misconceptions about longevity, a new organization aims to engage people who create culture.
- [New Foundation Unites Hollywood and the Arts Against Aging](https://www.lifespan.io/news/new-foundation-unites-hollywood-and-the-arts-against-aging/) - ALSAE today announced its official launch, pioneering a new nonprofit effort to accelerate progress against the chronic diseases of aging.
- [Impact of Off-Label Low-Dose Rapamycin on Healthy Adults](https://www.lifespan.io/news/impact-of-off-label-low-dose-rapamycin-on-healthy-adults/) - While there is plenty of preclinical data regarding rapamycin, there is no sufficient evidence that low-dose rapamycin use can extend healthspan and lifespan.
- [Partial Reprogramming Enhances Nerve Repair in Rats](https://www.lifespan.io/news/partial-reprogramming-enhances-nerve-repair-in-rats/) - A team of researchers has explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability to older animals.
- [Agentic AI Against Aging Hackathon](https://www.lifespan.io/news/agentic-ai-against-aging-hackathon/) - HackAging.ai is the global online hackathon at the intersection of Agentic AI and longevity science, bringing together researchers, founders, and engineers.
- [Cell Cycle Stage Impacts the Efficacy of Senotherapeutics](https://www.lifespan.io/news/cell-cycle-stage-impacts-the-efficacy-of-senotherapeutics/) - The effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on when the senescent cell stopped dividing.
- [Rejuvenation Roundup September 2025](https://www.lifespan.io/news/rejuvenation-roundup-september-2025/) - Last month was full of news, including our new Public Longevity Group initiative along with our paper on Urolithin A being accepted into Aging Cell.
- [Countdown to the Longevity Investors Conference 2025](https://www.lifespan.io/news/countdown-to-the-longevity-investors-conference-2025/) - Longevity Investors, launched as the first industry event series fully focusing on investors, wants to connect investors to key opinion leaders in the industry.
- [Faulty Mitochondrial DNA Copying Might Cause Inflammaging](https://www.lifespan.io/news/faulty-mitochondrial-dna-copying-might-cause-inflammaging/) - A possible mechanism behind age-related inflammation involves wrong building blocks being incorporated into mitochondrial DNA during replication.
- [YouthBio Therapeutics Announces Positive FDA Feedback](https://www.lifespan.io/news/youthbio-therapeutics-announces-positive-fda-feedback/) - YouthBio Therapeutics today announced a successful INTERACT meeting with the FDA for its lead Alzheimer's candidate, YB002.
- [A Combination Greatly Extends Lifespan in Male Mice](https://www.lifespan.io/news/a-combination-greatly-extends-lifespan-in-male-mice/) - The Conboy lab in Berkeley has discovered a treatment combination that greatly extends lifespan in old male mice and published its findings in Aging.
- [LongX Launches 2nd Edition of the Xplore Program](https://www.lifespan.io/news/longx-launches-2nd-edition-of-the-xplore-program/) - LongX, an initiative dedicated to providing avenues into the longevity space, announced a call for applications for the 2025 Xplore Program.
- [New Universal Therapy Effective in Multiple Tumor Types](https://www.lifespan.io/news/new-universal-therapy-effective-in-multiple-tumor-types/) - Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars abundant in cancer cells.
- [A Potential Reason Why Clotting Increases With Age](https://www.lifespan.io/news/a-potential-reason-why-clotting-increases-with-age/) - Researchers have described a method by which platelets are rapidly generated from hematopoietic stem cells (HSCs), bypassing intermediate cell types.
- [Personalized Medicine Approach to Senolytics Clinical Trials](https://www.lifespan.io/news/personalized-medicine-approach-to-senolytics-clinical-trials/) - Recent commentary in Nature Aging summarized clinical trials for senolytics and discussedfuture trials that use personalized medicine approaches.
- [Exercise Suppresses Appetite via a Brain Pathway](https://www.lifespan.io/news/exercise-suppresses-appetite-via-a-brain-pathway/) - Scientists have found a pathway behind the known effect of exercise suppressing appetite: a lactate-related metabolite that acts directly on certain neurons.
- [Some Bioethicists Promote Lifespan Limitation](https://www.lifespan.io/news/some-bioethicists-promote-lifespan-limitation/) - A paper published in Bioethics makes a startling case for people to die at 100 years old rather than live as long as they might choose.
- [AI Model Accurately Predicts Multiple Disease Risks](https://www.lifespan.io/news/ai-model-accurately-predicts-multiple-disease-risks/) - European scientists have created a GPT-based model that can predict the risk of more than a thousand diseases on par with biomarker-based models.
- [Lifespan Research Institute Launches Public Longevity Group](https://www.lifespan.io/news/lifespan-research-institute-launches-public-longevity-group/) - The Public Longevity Group is a new initiative focused on bridging the cultural gap between scientific breakthroughs in aging and their public acceptance.
- [Lipid Metabolism Is Causal in Some Alzheimer's Cases](https://www.lifespan.io/news/lipid-metabolism-is-causal-in-some-alzheimers-cases/) - In Aging Cell, researchers have outlined the relationship between Alzheimer's, increased pain sensitivity, and the enzyme LPCAT2.
- [Looking Back at Summer, Looking Forward to Growth](https://www.lifespan.io/news/looking-back-at-summer-looking-forward-to-growth/) - In the Northern Hemisphere, autumn is underway. Let us see what the Lifespan team has been working on to help our field keep us healthy.
- [Partial Reprogramming Rejuvenates Aged Cells and Tissues](https://www.lifespan.io/news/partial-reprogramming-rejuvenates-aged-cells-and-tissues/) - In a recent study, researchers investigated aging- and disease-associated changes in gene expression related to epithelial-mesenchymal transition.
- [A Short-Term High-Fat Diet Harms Memory in Mice](https://www.lifespan.io/news/a-short-term-high-fat-diet-harms-memory-in-mice/) - Two days on a Western-like high-fat diet reduce hippocampal glucose availability, which activates a subset of inhibitory neurons and causes memory problems.
- [How Macrophages Manage Obesity and Change With Age](https://www.lifespan.io/news/how-macrophages-manage-obesity-and-change-with-age/) - Researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function.
- [Microplastics Cause Cognitive Deficits in APOE4 Mice](https://www.lifespan.io/news/microplastics-cause-cognitive-deficits-in-apoe4-mice/) - Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3.
- [Epigenetic Clocks Do Not Perfectly Capture Metabolic Health](https://www.lifespan.io/news/epigenetic-clocks-do-not-perfectly-capture-metabolic-health/) - Researchers have published their surprising findings that epigenetic clocks are not significantly related to general metabolic health after weight loss.
- [Regular Glucosamine Use Linked to Fewer Chronic Diseases](https://www.lifespan.io/news/regular-glucosamine-use-linked-to-fewer-chronic-diseases/) - An analysis of UK Biobank data showed an association between regular glucosamine use and significantly lower risks of seven non-communicable chronic diseases.
- [Microglial Aging Is Determined by Their Environment](https://www.lifespan.io/news/microglial-aging-is-determined-by-their-environment/) - he local brain environment is the primary driver of microglial aging. After being transplanted into old brains, young cells adopted aged characteristics.
- [Study Boosts Brain Mitochondria, Rescues Memory in Mice](https://www.lifespan.io/news/study-boosts-brain-mitochondria-rescues-memory-in-mice/) - Scientists have found a way to directly stimulate the assembly of Complex I in mitochondria, rescuing memory deficits in models of Alzheimer’s and dementia.
- [A Mechanism Behind Protein Aggregation Discovered](https://www.lifespan.io/news/a-mechanism-behind-protein-aggregation-discovered/) - Scientists have found a pathway that regulates protein aggregation, a cause of several age-related neurodegenerative diseases.
- [Two People Almost Died at RAADfest. We Went to the Experts.](https://www.lifespan.io/news/two-people-almost-died-at-raadfest-we-went-to-the-experts/) - Two people nearly died, and several more sought treatment, after receiving peptide injections at the last RAADfest in Las Vegas.
- [A Non-Viral Gene Therapy Restores Mouse Hearts](https://www.lifespan.io/news/a-non-viral-gene-therapy-restores-mouse-hearts/) - A recent study investigated the roles of brown adipose tissue and a lipid-controlling hormone, 12,13-diHOME, in cardiac health.
- [Cancer Cells Transfer Mitochondria to Fibroblasts](https://www.lifespan.io/news/cancer-cells-transfer-mitochondria-to-fibroblasts/) - Scientists have discovered that cancer cells recruit fibroblasts to support tumor growth by transferring mitochondria into them.
- [Rejuvenation Roundup August 2025](https://www.lifespan.io/news/rejuvenation-roundup-august-2025/) - Researchers discovered how well-known substances can confer physical benefits, delivered compounds in new ways, and continued to develop new forms of medicine.
- [Moderate Beer Consumption Produces Benefits in Mice](https://www.lifespan.io/news/moderate-beer-consumption-produces-benefits-in-mice/) - Scientists have given three types of beer to artificially aged male mice and recorded numerous benefits, including microbiome diversity and lipid profiles.
- [Loose Chromatin, Senescent Inflammation, and Cancer](https://www.lifespan.io/news/loose-chromatin-senescent-inflammation-and-cancer/) - In Aging Cell, researchers have reported that chromatin demethylation allows SASP compounds to be more easily expressed.
- [Rejuvenating Atherosclerotic Foam Cells](https://www.lifespan.io/news/rejuvenating-atherosclerotic-foam-cells/) - According to a study published by Cyclarity Therapeutics, its drug UDP-003 shows benefits in reversing the root cause of atherosclerotic plaques
- [Impaired Brain Blood Flow Might Be Important in Alzheimer’s](https://www.lifespan.io/news/impaired-brain-blood-flow-might-be-important-in-alzheimers/) - Scientists have developed a potent diagnostic tool based on the vascular hypothesis for Alzheimer’s. It outperformed three current techniques.
- [Revive ME to Spotlight Healthy Longevity in Abu Dhabi](https://www.lifespan.io/news/revive-me-to-spotlight-healthy-longevity-in-abu-dhabi/) - Abu Dhabi will host a conference dedicated to longevity, biotechnology, regenerative medicine, personalised wellness, and AI-powered healthcare, Revive ME.
- [Reducing an Iron-Associated Protein Fights Cognitive Decline](https://www.lifespan.io/news/reducing-an-iron-associated-protein-fights-cognitive-decline/) - Researchers have described how an increase in the iron-associated protein ferritin light chain 1 (FTL1) is related to age-related cognitive impairment.
- [Transient Epigenetic Rejuvenation Recorded in Athletes](https://www.lifespan.io/news/transient-epigenetic-rejuvenation-recorded-in-athletes/) - Professional soccer players experience a drop in their biological age after a match as measured by biomarkers assessed with state-of-the-art methylation clocks.
- [Researchers Identify a Key Senescence-Spreading Factor](https://www.lifespan.io/news/researchers-identify-a-key-senescence-spreading-factor/) - In Metabolism Clinical & Experimental, researchers have described how the reduced isoform of the SASP factor HMGB1 causes senescence to spread.
- [Low-Dose Lithium Reverses Features of Alzheimer’s in Mice](https://www.lifespan.io/news/low-dose-lithium-reverses-features-of-alzheimers-in-mice/) - Researchers identified the critical role that lithium plays in brain health and the development of mild cognitive impairment and Alzheimer’s disease.
- [Exosomes Reduce Sarcopenia in a Mouse Model](https://www.lifespan.io/news/exosomes-reduce-sarcopenia-in-a-mouse-model/) - Exosomes secreted by mesenchymal stem cells derived from human umbilical cord tissue (hucMSC-Exos) restore muscle function in a mouse model of sarcopenia.
- [An Overly Youthful Immune System Might Cause Autoimmunity](https://www.lifespan.io/news/an-overly-youthful-immune-system-might-cause-autoimmunity/) - Immune aging might be necessary to shield people from autoimmune effects, as the repertoire of autoantigens expands with age.
- [Moving to a More Walkable City Increases Step Count](https://www.lifespan.io/news/moving-to-a-more-walkable-city-increases-step-count/) - Working with smartphone-based data, scientists have shown for the first time that relocating to a more walkable city is linked to increased daily step counts.
- [How Inflammation Is Linked to Heart Disease](https://www.lifespan.io/news/how-inflammation-is-linked-to-heart-disease/) - Researchers have published a detailed review on the relationship between cardiovascular disease and the age-related inflammation known as inflammaging.
- [Cannabis as a Treatment for Age-Related Diseases](https://www.lifespan.io/news/cannabis-as-a-treatment-for-age-related-diseases/) - Researchers have recently published a review on how cannabis use among older adults impacts age-related conditions and longevity.
- [Lifespan Alliance Launch & New Leadership at LRI](https://www.lifespan.io/news/lifespan-alliance-launch-new-leadership-at-lri/) - Lifespan Research Institute, a nonprofit leader in longevity science and advocacy, announces the launch of the Lifespan Alliance.
- [Nir Barzilai: “Positive Evidence for Metformin is Mounting”](https://www.lifespan.io/news/nir-barzilai-positive-evidence-for-metformin-is-mounting/) - Dr. Nir Barzilai, the director of the Institute for Aging Research at the Albert Einstein College of Medicine, is one of geroscience's most prominent figures.
- [How FGF21 Fights Back Against a Muscle-Wasting Disease](https://www.lifespan.io/news/how-fgf21-fights-back-against-a-muscle-wasting-disease/) - Researchers have reported on how an increase in FGF21, a myokine that encourages muscle growth, impacts the progression of amyotrophic lateral sclerosis (ALS).
- [Mitochondria Transplant Improves Chemotherapy in Lung Cancer](https://www.lifespan.io/news/mitochondria-transplant-improves-chemotherapy-in-lung-cancer/) - Injecting healthy mitochondria either systematically or directly into the tumor microenvironment boosts the efficiency of a standard anti-cancer therapy.
- [A Better Extracellular Matrix Makes Aged Cells Act Youthful](https://www.lifespan.io/news/a-better-extracellular-matrix-makes-aged-cells-act-youthful/) - Growing older cells in a youthful medium causes them to behave and function more like younger cells, suggesting a new method of creating stem cell therapies.
- [Nicotine Consumption Improves Motor Functions in Male Mice](https://www.lifespan.io/news/nicotine-consumption-improves-motor-functions-in-male-mice/) - Long-term nicotine consumption has a positive impact on motor function in male mice. The beneficial effects are mediated by sphingolipid and NAD+ metabolism.
- [Study Paves Road for Oral Delivery of Proteins](https://www.lifespan.io/news/study-paves-road-for-oral-delivery-of-proteins/) - Using a pathogen-originated protein and a human antibody, scientists have created a chimeric construct that can deliver protein cargo via the intestine.
- [A Brain Clock for Finding Rejuvenating Medications](https://www.lifespan.io/news/a-brain-clock-for-finding-rejuvenating-medications/) - Researchers have developed a transcription-based clock that estimates brain age and used it to identify potential interventions against neurodegeneration.
- [Study Finds Metformin's Action Is Regulated by the Brain](https://www.lifespan.io/news/study-finds-metformins-action-is-regulated-by-the-brain/) - A new study has shown that, unlike many other glucose-lowering drugs, metformin is regulated by the protein Ras1 in a specific subset of neurons.
- [Rejuvenation Roundup July 2025](https://www.lifespan.io/news/rejuvenation-roundup-july-2025/) - Summer is heating things up, both in the Northern Hemisphere and in the world of rejuvenation biotechnology. Here's what's happened in July.
- [Rejuvenating Muscles in Mice With Senomorphic Treatment](https://www.lifespan.io/news/rejuvenating-muscles-in-mice-with-senomorphic-treatment/) - A recent study investigated skeletal muscle tissue and found that the antiviral drug maraviroc reduces senescence and improves muscle health in aged mice.
- [The 2025 Longevity Summit Dublin](https://www.lifespan.io/news/the-2025-longevity-summit-dublin/) - The 2025 Longevity Summit Dublin was held in July, and we have the highlights from the event along with research updates and news from the conference.
- [The Tale of One Tower: SF-Based Vertical Longevity Village](https://www.lifespan.io/news/the-tale-of-one-tower-sf-based-vertical-longevity-village/) - In downtown San Francisco, an entire tower is becoming a hub for longevity, AI, crypto, and robotics. It just hosted its first longevity conference.
- [Senescent Cells, Osteoporosis, and Alzheimer's Are Linked](https://www.lifespan.io/news/senescent-cells-osteoporosis-and-alzheimers-are-linked/) - Researchers publishing in Nature Aging have discovered how Alzheimer's-related protein aggregates are also related to senescent cells and osteoporosis.
- [Fighting Osteoarthritis by Targeting Fatty Acids](https://www.lifespan.io/news/fighting-osteoarthritis-by-targeting-fatty-acids/) - In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production.
- [7,000 Steps a Day Are Enough for Most Benefits](https://www.lifespan.io/news/7000-steps-a-day-are-enough-for-most-benefits/) - A massive new meta-analysis confirms that 10,000 daily steps are not required for most of the health benefits of walking. Around 7,000 seems to be right.
- [A Gene That Keeps Cells Under Control](https://www.lifespan.io/news/a-gene-that-keeps-cells-under-control/) - Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation.
- [Organ-Specific Aging Analysis Reveals Disease Connections](https://www.lifespan.io/news/organ-specific-aging-analysis-reveals-disease-connections/) - Researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific proteins found in plasma
- [FDA-Approved Drug Combo Rescues Alzheimer’s in Mice](https://www.lifespan.io/news/fda-approved-drug-combo-rescues-alzheimers-in-mice/) - Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates against Alzheimer’s.
- [6th TimePie Longevity Forum](https://www.lifespan.io/news/china-longevity-forum/) - As China’s population ages rapidly, the development of the longevity industry has been prioritized to the level of national strategy since 2024.
- [Vesicles From Antler Cells Restore Bone in Monkeys](https://www.lifespan.io/news/vesicles-from-antler-cells-restore-bone-in-monkeys/) - Researchers have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells restore bone mass to rhesus macaques.
- [AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial](https://www.lifespan.io/news/ai-reveals-a-hidden-effect-in-a-failed-alzheimers-trial/) - An AI model stratifies Alzheimer’s patients into slow or rapid subgroups. In a real-world failed trial, it revealed a robust effect in the former subgroup.
- [Scientists Successfully Edit Mitochondrial DNA](https://www.lifespan.io/news/scientists-successfully-edit-mitochondrial-dna/) - A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells.
- [OS-01 Peptide Tested in Skin Aging Pilot Study](https://www.lifespan.io/news/os-01-peptide-tested-in-skin-aging-pilot-study/) - A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01.
- [Mitochondrial Damage May Drive Type 2 Diabetes](https://www.lifespan.io/news/mitochondrial-damage-may-drive-type-2-diabetes/) - A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells to lose their identity and malfunction.
- [Maintaining Telomeres Extends Lifespan in Mice](https://www.lifespan.io/news/maintaining-telomeres-extends-lifespan-in-mice/) - A study has found that the overexpression of telomerase reverse transcriptase (TERT) leads to lifespan extension in mice without significant side effects.
- [How Part of the Krebs Cycle Affects Senescence](https://www.lifespan.io/news/how-part-of-the-krebs-cycle-affects-senescence/) - Researchers have discovered how and why α-ketoglutaric acid (AKG) affects cellular senescence and how a small molecule may be useful in affecting this process.
- [Dietary Patterns Associated With Healthy Aging](https://www.lifespan.io/news/dietary-patterns-associated-with-healthy-aging/) - A study investigated the impact of eight different mid-life dietary patterns on the odds of healthy aging, including cognitive, mental, and physical health.
- [A New Study Claims to Challenge Peto’s Paradox](https://www.lifespan.io/news/a-new-study-claims-to-challenge-petos-paradox/) - Applying statistical methods to a large dataset spanning almost 300 species, scientists found a positive correlation between body size and cancer prevalence.
- [Engineered Stem Cells Reduce Lung Fibrosis in Mice](https://www.lifespan.io/news/engineered-stem-cells-reduce-lung-fibrosis-in-mice/) - esearchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model.
- [A Hallucinogenic Mushroom Compound Extends Mouse Lifespan](https://www.lifespan.io/news/a-hallucinogenic-mushroom-compound-extends-mouse-lifespan/) - Researchers investigated psilocybin for its anti-aging properties. t extends cellular and organismal lifespan, even when administered later in life.
- [Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice](https://www.lifespan.io/news/non-toxic-stem-cell-transplantation-prevents-cancer-in-mice/) - A protocol for hematopoietic stem cell transplantation reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity.
- [How Blood-Brain Barrier Leaks Make Parkinson's Worse](https://www.lifespan.io/news/how-blood-brain-barrier-leaks-make-parkinsons-worse/) - Researchers have discovered how α-synuclein, a key protein in Parkinson's diseas, leads to inflammation and disruption of the axons in the brain.
- [Senolytics May Affect Inflammation-Related Cognitive Decline](https://www.lifespan.io/news/senolytics-may-affect-inflammation-related-cognitive-decline/) - Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that senolytics can ameliorate this.
- [Molecular Similarities Between Cigarette Smoking and Aging](https://www.lifespan.io/news/molecular-similarities-between-cigarette-smoking-and-aging/) - Researchers have learned that smoking acts as an aging accelerator and involves molecular changes in tissues beyond those directly exposed to cigarette smoke.
- [Springtime for the Longevity Industry](https://www.lifespan.io/news/springtime-for-the-longevity-industry/) - If you are in the Northern Hemisphere, then spring is well underway and the weather is warming up. This is the season of renewal and growth.
- [Longevity Policy, Advocacy in the Spotlight at Vitalist Bay](https://www.lifespan.io/news/longevity-policy-advocacy-in-the-spotlight-at-vitalist-bay/) - This conference was an important first attempt to kick-start a discussion about how the longevity movement can take over the global agenda.
- [Inflammaging Might Not Be Universal Across Populations](https://www.lifespan.io/news/inflammaging-might-not-be-universal-across-populations/) - By comparing data from industrialized and non-industrialized societies, a new study calls into question some assumptions about inflammation and aging.
- [Five Hallmarks of Stem Cell Aging Proposed](https://www.lifespan.io/news/five-hallmarks-of-stem-cell-aging-proposed/) - In Cell Stem Cell, a trio of reviewers has proposed five behavior-based hallmarks that are specific to the aging of stem cells.
- [Dr. David Furman on Inflammation and Aging](https://www.lifespan.io/news/dr-david-furman-on-inflammation-and-aging/) - Dr. David Furman, who has been studying inflammation at Stanford and the Buck Institute, might be the best authority to talk to about inflammation and aging.
- [Fixing Sugar Metabolism Shows Promise Against Dementia](https://www.lifespan.io/news/fixing-sugar-metabolism-shows-promise-against-dementia/) - Scientists have shown that aberrant metabolism of glycogen in neurons is linked to the accumulation of harmful tau protein.
- [Researchers Connect Cellular Markers to Physical Well-Being](https://www.lifespan.io/news/researchers-connect-cellular-markers-to-physical-well-being/) - In Aging Cell, a team of researchers has described how the health of skin fibroblasts relates to physical and functional ability.
- [Healthspan Effects of an Anti-Aging Vaccine on Mice](https://www.lifespan.io/news/healthspan-effects-of-an-anti-aging-vaccine-on-mice/) - Researchers described their novel CD38 peptide vaccine, which improved many measurements of physical health and prevented cognitive decline in aged mice.
- [Study Discovers a Mammalian Mechanism of Tissue Regeneration](https://www.lifespan.io/news/study-discovers-a-mammalian-mechanism-of-tissue-regeneration/) - Scientists have analyzed the differences between mammalian species that can regrow ear tissue after injury and those that cannot.
- [Rejuvenation Roundup June 2025](https://www.lifespan.io/news/rejuvenation-roundup-june-2025/) - This month, in between reporting on new methods of affecting aging at its most basic levels, we caught up with AI developers and a longevity fund.
- [Researchers Identify a New Dementia Target](https://www.lifespan.io/news/researchers-identify-a-new-dementia-target/) - Excessive amounts of complement C3, an essential immune protein that increases with aging, are responsible for causing dementia in a mouse model.
- [Subcutaneous and Visceral Fat React Differently to Obesity](https://www.lifespan.io/news/subcutaneous-and-visceral-fat-react-differently-to-obesity/) - Scientists have found that visceral fat and subcutaneous fat produce different responses to obesity in male mice and human patients.
- [Gamma Delta T Cells Show Promise Against Cellular Senescence](https://www.lifespan.io/news/gamma-delta-t-cells-show-promise-against-cellular-senescence/) - Scientists have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis.
- [Using a Surface Biomarker to Target Senescent Cells](https://www.lifespan.io/news/using-a-surface-biomarker-to-target-senescent-cells/) - Scientists have identified a senescence-associated surface protein that can be targeted using antibodies and published their work as a pre-print.
- [Targeting an Inflammatory Pathway Fights Alzheimer’s](https://www.lifespan.io/news/targeting-an-inflammatory-pathway-fights-alzheimers/) - Scientists have discovered that a rare mutation protects against Alzheimer’s disease by dampening a central inflammatory pathway.
- [Lipid Metabolite Rejuvenates Muscle Stem Cells in Mice](https://www.lifespan.io/news/lipid-metabolite-rejuvenates-muscle-stem-cells-in-mice/) - A recent study investigated the effect of a single treatment of prostaglandin E2 on improving muscle strength and rejuvenating muscle stem cells in mice.
- [Senolytics May Treat Some Long-Term Viral Lung Damage](https://www.lifespan.io/news/senolytics-may-treat-some-long-term-viral-lung-damage/) - Mice exposed to influenza experience long-term consequences that can be partially ameliorated with the senolytic drug navitoclax.
- [Engineering Microglia to Deliver an Anti-Alzheimer's Drug](https://www.lifespan.io/news/engineering-microglia-to-deliver-an-anti-alzheimers-drug/) - In Cell Stem Cell, researchers have described how genetically engineered microglia can be used to deliver therapeutic proteins to the brain.
- [Longer Reproductive Spans Linked to Younger Brains in Women](https://www.lifespan.io/news/longer-reproductive-spans-linked-to-younger-brains-in-women/) - Women with longer reproductive spans, earlier first period (menarche), and later menopause may experience slower brain aging.
- [Young Plasma Decreases Inflammation After Surgery in Trial](https://www.lifespan.io/news/young-plasma-decreases-inflammation-after-surgery-in-trial/) - A randomized, controlled clinical trial demonstrated that plasma proteins from young donors have beneficial effects against inflammation in a surgical context.
- [Rejuve.AI: Just Another App or a Longevity Research Network?](https://www.lifespan.io/news/rejuve-ai-just-another-app-or-a-longevity-research-network/) - On its website, Rejuve.AI, a company co-founded by its dynamic CEO, Jasmine Smith, and a renowned AI researcher, Ben Goertzel, promises a lot of things
- [Financial Behavior Might Help Diagnose Dementia Early](https://www.lifespan.io/news/financial-behavior-might-help-diagnose-dementia-early/) - SScientists have identified various financial behaviors that might point to dementia years before it leads to loss of financial capacity.
- [A New Method of Modifying Stem Cells](https://www.lifespan.io/news/a-new-method-of-modifying-stem-cells/) - Researchers have investigated a never-before-used method of transfecting senescent mesenchymal stem cells (MSCs) that appears to be safer than others.
- [A Popular Sweetener Adversely Affects Blood Vessels](https://www.lifespan.io/news/a-popular-sweetener-adversely-affects-blood-vessels/) - A new study has lent more support to previous epidemiological data that ties the popular sugar substitute erythritol to elevated cardiovascular risk.
- [Preventing CRISPR From Causing Senescence](https://www.lifespan.io/news/preventing-crispr-from-causing-senescence/) - Researchers have taken a look at what causes CRISPR/Cas9 gene-editing technology to drive cells senescent and investigated a potential method of preventing it.
- [How Gut Microbiota Impact Endothelial Cell Senescence](https://www.lifespan.io/news/how-gut-microbiota-impact-endothelial-cell-senescence/) - Researchers demonstrated that gut microbes and their metabolites can profoundly influence the senescence of endothelial cells.
- [New Study Could Pave the Way for Better Cancer Vaccines](https://www.lifespan.io/news/new-study-could-pave-the-way-for-better-cancer-vaccines/) - Only about 1% of presented tumor antigens come from oncogenic mutations. The remaining 99%, previously overlooked, may offer better treatment targets.
- [Younger Cohorts Show Less Dementia at the Same Age](https://www.lifespan.io/news/younger-cohorts-show-less-dementia-at-the-same-age/) - While the overall prevalence of dementia might be rising due to population aging, today’s older people seem to be less prone to dementia than in the past.
- [New Insights Into How Neural Stem Cells Age](https://www.lifespan.io/news/new-insights-into-how-neural-stem-cells-age/) - Researchers publishing in Aging Cell have used single-cell transcriptomics to discover new insights into how neural stem cells (NSCs) change with aging.
- [How Plasma Exchange Affects Aging in a Human Trial](https://www.lifespan.io/news/how-plasma-exchange-affects-aging-in-a-human-trial/) - A placebo-controlled clinical trial has determined that plasma derived from younger donors has beneficial effects when combined with immunoglobulin.
- [Rejuvenation Roundup May 2025](https://www.lifespan.io/news/rejuvenation-roundup-may-2025/) - May was a substantial month in the rejuvenation biotechnology world, including nanomedical advancements and T cells to fight senescence.
- [Educated ‘Night Owls’ Might Have More Cognitive Decline Risk](https://www.lifespan.io/news/educated-night-owls-might-have-more-cognitive-decline-risk/) - An analysis of over 20,000 middle-aged and older adults showed an association between being a night owl and cognitive decline among highly educated people.
- [Blunting an Inflammatory Pathway Slows Alzheimer’s in Mice](https://www.lifespan.io/news/blunting-an-inflammatory-pathway-slows-alzheimers-in-mice/) - Scientists have demonstrated that knocking out part of the cGAS-STING DNA-sensing pathway slows disease progression in a mouse model of Alzheimer’s.
- [A Drug Combo Increases Lifespan in Mice by Over 30%](https://www.lifespan.io/news/a-drug-combo-increases-lifespan-in-mice-by-over-30/) - Combining rapamycin with the anti-cancer drug trametinib produced a synergistic effect and robust life extension in a new study.
- [Circulate Health Publishes Results of Multiomics Study](https://www.lifespan.io/news/circulate-health-publishes-results-of-multiomics-study/) - Circulate Health, dedicated to harnessing the potential of therapeutic plasma exchange, announced the publication of a single blind, human clinical trial.
- [Why Some Mammals Live Much Longer Than Others](https://www.lifespan.io/news/why-some-mammals-live-much-longer-than-others/) - A recent study investigated differences in maximum lifespan among mammals. The researchers found associations between copied genes, lifespan, and brain size.
- [DNA Methylation Patterns Trace Blood Aging Dynamics](https://www.lifespan.io/news/dna-methylation-patterns-trace-blood-aging-dynamics/) - Scientists have created a new method of tracing blood cells’ lineage. This can improve our understanding of clonal hematopoiesis and its impact on aging.
- [Caloric Restriction Slows Ovarian Aging in Monkeys](https://www.lifespan.io/news/caloric-restriction-slows-ovarian-aging-in-monkeys/) - Three years of caloric restriction in rhesus macaque monkeys that are beginning to enter menopause slows their ovarian aging.
- [Vitamin D Rescues Telomere Attrition in Leukocytes](https://www.lifespan.io/news/vitamin-d-rescues-telomere-attrition-in-leukocytes/) - A sub-study, which was part of the large-scale VITAL trial, determined that vitamin D supplementation slows telomere attrition in leukocytes almost to a halt.
- [Common Laboratory Mice Age Faster in a Natural Environment](https://www.lifespan.io/news/common-laboratory-mice-age-faster-in-a-natural-environment/) - In Aging Cell, researchers have found that exposing ordinary Black 6 mice to a more natural environment accelerates rather than slows the aging of their livers.
- [Dietary Methionine Restriction Improves Healthspan in Mice](https://www.lifespan.io/news/dietary-methionine-restriction-improves-healthspan-in-mice/) - In a recent study, researchers investigated how restricting dietary methionine and inhibiting the tyrosine degradation pathway affects healthspan in aged mice.
- [Nanostructures Trap Amyloid Beta, Rescuing Neurons](https://www.lifespan.io/news/nanostructures-trap-amyloid-beta-rescuing-neurons/) - Scientists have created engineered nanostructures that bind monomers and oligomers of harmful amyloid beta (Aβ) protein, preventing its entry into neurons.
- [Results of a Phase 1 Trial of Senolytics for Alzheimer's](https://www.lifespan.io/news/results-of-a-phase-1-trial-of-senolytics-for-alzheimers/) - A Phase 1 trial of the well-known senolytic combination of dasatinib and quercetin in patients with Alzheimer's disease has been published in Neurotherapeutics.
- [Is Aging Part of the Immune System?](https://www.lifespan.io/news/is-aging-part-of-the-immune-system/) - Peter Lidsky's lab has constructed a model that supports the view of programmed aging as an evolutionary adaptation to pathogens.
- [Well-Known Researchers Discuss Personalized Aging Treatments](https://www.lifespan.io/news/well-known-researchers-discuss-personalized-aging-treatments/) - The Hallmarks of Aging team has returned to Cell, publishing a detailed review discussing how future methods of dealing with aging might be highly personalized.
- [2060 Longevity Forum: Future Health Meets Smartest Capital](https://www.lifespan.io/news/2060-longevity-forum-future-health-meets-smartest-capital/) - The South of France will host the first edition of the 2060 Longevity Forum, a groundbreaking event that positions longevity as a great investment opportunity.
- [How Apigenin May Reduce Senescence and Cancer](https://www.lifespan.io/news/how-apigenin-may-reduce-senescence-and-cancer/) - Screening of a natural compounds library has revealed the senomorphic properties of apigenin and rejuvenating effects on many age-related molecular features.
- [Michael Levin on Bioelectricity in Development and Aging](https://www.lifespan.io/news/michael-levin-on-bioelectricity-in-development-and-aging/) - Michael Levin, professor at Tufts University, has been working for years on how bioelectrical patterns affect development and aging.
- [A New Approach to Treating Aging Skin](https://www.lifespan.io/news/a-new-approach-to-treating-aging-skin/) - Researchers publishing in Aging Cell have found a pathway that leads skin cells to become senescent along with a potential target for future therapies.
- [Fasting Affects the Immune System via the Brain](https://www.lifespan.io/news/fasting-affects-the-immune-system-via-the-brain/) - A new study has found that the immune remodeling associated with fasting can be recapitulated by activating a subset of neurons in the hypothalamus.
- [Young Microbiota Transfer Reduces Aging Aspects in Mice](https://www.lifespan.io/news/young-microbiota-transfer-reduces-aging-aspects-in-mice/) - Lifelong, repeated microbiota transfer from young mice to old mice improves intestinal permeability, coordinative ability, and metabolic profiles.
- [TFEB Lets Cells Live Long Enough to Become Senescent](https://www.lifespan.io/news/tfeb-lets-cells-live-long-enough-to-become-senescent/) - In Aging Cell, researchers have explained how transcription factor EB (TFEB) is related to cellular senescence and keeps stressed cells alive.
- [Playing the Long Game Towards Radical Life Extension](https://www.lifespan.io/news/playing-the-long-game-towards-radical-life-extension/) - The ambition to defeat aging is not just about building better airplanes; it’s about realizing that no airplane, no matter how refined, can reach the Moon.
- [Limiting One Protein Maintenance Pathway Enhances Another](https://www.lifespan.io/news/limiting-one-protein-maintenance-pathway-enhances-another/) - In Aging Cell, researchers have explored how transcription factor EB (TFEB) promotes proteostasis in a common aging model.
- [Results of a Crowdfunded One-Year Human Rapamycin Trial](https://www.lifespan.io/news/results-of-a-crowdfunded-one-year-human-rapamycin-trial/) - In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL).
- [Rejuvenation Roundup April 2025](https://www.lifespan.io/news/rejuvenation-roundup-april-2025/) - While AI continues to accelerate, human beings still have to contend with aging. Here's some of what's been done to support longer, healthier lives in April.
- [The mTOR Inhibitors Lifespan Project Enters Next Phase](https://www.lifespan.io/news/the-mtor-inhibitors-lifespan-project-enters-next-phase/) - Ora Biomedical announces the successful funding of the first subproject under its ambitious initiative to conduct a rapid lifespan analysis of mTOR inhibitors.
- [Impact of Butter and Plant-Based Oils on Mortality](https://www.lifespan.io/news/impact-of-butter-and-plant-based-oils-on-mortality/) - A study published in JAMA Internal Medicine suggests that a higher intake of butter is associated with increased mortality. [1].
- [Immune Resilience Is a Strong Determinant of Mortality](https://www.lifespan.io/news/immune-resilience-is-a-strong-determinant-of-mortality/) - A study defines the concept of immune resilience as a determinant of aging, linking it to survival, inflammation,, and the ability to withstand stress.
- [How Extracellular Vesicles From Stem Cells Fight Senescence](https://www.lifespan.io/news/how-extracellular-vesicles-from-stem-cells-fight-senescence/) - Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence.
- [How Fisetin May Fight Blood Vessel Calcification](https://www.lifespan.io/news/how-fisetin-may-fight-blood-vessel-calcification/) - Researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in cells and mice.
- [Technology Use Associated With Reduced Cognitive Impairment](https://www.lifespan.io/news/technology-use-associated-with-reduced-cognitive-impairment/) - Research suggests that digital technologies provide beneficial effects on cognition in middle-aged and older adults who did not grow up with such technologies.
- [Researchers Fight Some Mutations by Targeting Mitochondria](https://www.lifespan.io/news/researchers-fight-some-mutations-by-targeting-mitochondria/) - Clonal hematopoiesis can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin.
- [A Senescence-Related Target for Blood Vessel Formation](https://www.lifespan.io/news/a-senescence-related-target-for-blood-vessel-formation/) - In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target for arterial clogs.
- [Researchers Use Big Data to Find a Longevity Target](https://www.lifespan.io/news/researchers-use-big-data-to-find-a-longevity-target/) - Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk.
- [The Underexplored Applications of Longevity Biotechnology](https://www.lifespan.io/news/the-underexplored-applications-of-longevity-biotechnology/) - No other human endeavor today holds more promise than understanding aging. From applications to beneficiaries, the potential of targeting aging is vast.
- [Senolytics Decrease Low Back Pain in Mice](https://www.lifespan.io/news/senolytics-decrease-low-back-pain-in-mice/) - Researchers have tested a synthetic and natural combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration.
- [Neurons Hidden to Immune Cells Improve Parkinson’s in Rats](https://www.lifespan.io/news/neurons-hidden-to-immune-cells-improve-parkinsons-in-rats/) - By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts to fight Parkinson’s.
- [How Exercise May Fight Parkinson's Disease](https://www.lifespan.io/news/how-exercise-may-fight-parkinsons-disease/) - Researchers have found a pathway through which exercise could fight Parkinson's disease and a molecule that might recapitulate this effect.
- [Joshua “Scotch” McClure: “Infectious Disease Drives Aging”](https://www.lifespan.io/news/joshua-scotch-mcclure-infectious-disease-drives-aging/) - Maxwell Biosciences has developed Claromers™, synthetic small molecules that mimic the natural immune system.
- [Reprogramming Epigenetics to Fight Back Pain](https://www.lifespan.io/news/reprogramming-epigenetics-to-fight-back-pain/) - A new paper has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model.
- [World's First Pig-to-Human Liver Transplant](https://www.lifespan.io/news/worlds-first-pig-to-human-liver-transplant/) - Chinese scientists announced the world’s first successful transplantation of a genetically modified pig liver into a brain-dead patient.
- [Extracellular Vesicles Restore Some Heart Function to Mice](https://www.lifespan.io/news/extracellular-vesicles-restore-some-heart-function-to-mice/) - Researchers have found that small extracellular vesicles (sEVs) derived from young mice alleviate heart dysfunction in older mice.
- [Activation of Silent X Chromosome Might Improve Cognition](https://www.lifespan.io/news/activation-of-silent-x-chromosome-might-improve-cognition/) - The genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging.
- [Scientists Discover a New Mitigator of Senescence](https://www.lifespan.io/news/scientists-discover-a-new-mitigator-of-senescence/) - Scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies.
- [Rejuvenation Roundup March 2025](https://www.lifespan.io/news/rejuvenation-roundup-march-2025/) - It's April Fool's Day, but until we prevent our bodies from gradually deteriorating, the joke will be on us. Here's what's been done to fight aging last month.
- [Changes in Aging Adrenal Glands Disturb Hormonal Balance](https://www.lifespan.io/news/changes-in-aging-adrenal-glands-disturb-hormonal-balance/) - Reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body.
- [Need for Cholesterol May Explain Alzheimer's Brain Patterns](https://www.lifespan.io/news/need-for-cholesterol-may-explain-alzheimers-brain-patterns/) - Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol.
- [Researchers Find New Target for Spinal Disc Degeneration](https://www.lifespan.io/news/researchers-find-new-target-for-spinal-disc-degeneration/) - Researchers have found a new avenue for approaching intervertebral disc degeneration and published their work in Aging Cell.
- [Anti-Amyloid Drug Reduces Alzheimer's Risk in Small Subgroup](https://www.lifespan.io/news/anti-amyloid-drug-reduces-alzheimers-risk-in-small-subgroup/) - The anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants.
- [Heat May Speed Up Epigenetic Aging in Older Adults](https://www.lifespan.io/news/heat-may-speed-up-epigenetic-aging-in-older-adults/) - Using epigenetic clocks, a recent study reported significant associations between increased heat days and accelerated epigenetic aging.
- [Scientists Create Cytoskeleton-Like Structures From RNA](https://www.lifespan.io/news/scientists-create-cytoskeleton-like-structures-from-rna/) - In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles.
- [A Core Senescence Biomarker Fights Inflammation](https://www.lifespan.io/news/a-core-senescence-biomarker-fights-inflammation/) - Researchers have found that p53, a biomarker and inducer of senescence, suppresses both inflammation and DNA damage in senescent cells.
- [A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model](https://www.lifespan.io/news/a-hypothalamus-neuropeptide-reduces-aging-in-a-mouse-model/) - Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus.
- [Short-Term Overeating Alters Brain Insulin Sensitivity](https://www.lifespan.io/news/short-term-overeating-alters-brain-insulin-sensitivity/) - Even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in obesity and type 2 diabetes.
- [Elamipretide, a Potential New Drug, Reduces Frailty in Mice](https://www.lifespan.io/news/elamipretide-a-potential-new-drug-reduces-frailty-in-mice/) - Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice.
- [Cellular Senescence Prevents Unlearning in Some Male Mice](https://www.lifespan.io/news/cellular-senescence-prevents-unlearning-in-some-male-mice/) - In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice.
- [Human Exposome Project Explores Environmental Disease Causes](https://www.lifespan.io/news/human-exposome-project-explores-environmental-disease-causes/) - The exposome, the totality of exposures individuals experience over their lives, is responsible for 10 times more mortality risk than genetic predisposition.
- [An Existing Diabetes Drug May Treat Aspects of Aging](https://www.lifespan.io/news/an-existing-diabetes-drug-may-treat-aspects-of-aging/) - Glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice.
- [A Klotho Gene Therapy Extends Life in Male Mice](https://www.lifespan.io/news/a-klotho-gene-therapy-extends-life-in-male-mice/) - Increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads to longer lifespans in male mice.
- [Ginkgolide B Improves Healthspan and Lifespan in Female Mice](https://www.lifespan.io/news/ginkgolide-b-improves-healthspan-and-lifespan-in-female-mice/) - The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved metrics and increased lifespan in female mice.
- [Genes Affect Aging and Mortality Less Than Extrinsic Factors](https://www.lifespan.io/news/genes-affect-aging-and-mortality-less-than-extrinsic-factors/) - A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence.
- [Rejuvenation Roundup February 2025](https://www.lifespan.io/news/rejuvenation-roundup-february-2025/) - February might be the shortest month, but it still has room for plenty of research and advancements. Here's what's happened over the last four weeks.
- [The Battle for Long Life Has Been Accomplished: What’s Next?](https://www.lifespan.io/news/the-battle-for-long-life-has-been-accomplished-whats-next/) - How long can people live? This is not just a foundational question in science. The answer has important public policy implications and is of interest to us all.
- [A Protein That Controls Senescent Cell Structure](https://www.lifespan.io/news/a-protein-that-controls-senescent-cell-structure/) - Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence.
- [Junevity Is Silencing RNA to Treat Obesity and Diabetes](https://www.lifespan.io/news/junevity-is-silencing-rna-to-treat-obesity-and-diabetes/) - Junevity pursues the ambitious goal of fixing age-related transcriptional dysregulation using short interfering RNAs, also known as silencing RNAs (siRNAs).
- [Effects of Estradiol and Progesterone on Knee Osteoarthritis](https://www.lifespan.io/news/effects-of-estradiol-and-progesterone-on-knee-osteoarthritis/) - Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women.
- [Receiving Care in Your Language Linked to Lower Health Risks](https://www.lifespan.io/news/receiving-care-in-your-language-linked-to-lower-health-risks/) - People with hypertension who receive care in their preferred language are less likely to have a major cardiovascular event or die from any cause.
- [A Generative, Foundational AI Model for Genetics](https://www.lifespan.io/news/a-generative-foundational-ai-model-for-genetics/) - The Arc Institute has published a manuscript on its creation of Evo 2, an AI foundation model that is capable of both understanding and building full genomes.
- [Impressions from Hevolution’s Global Healthspan Summit 2025](https://www.lifespan.io/news/impressions-from-hevolutions-global-healthspan-summit-2025/) - These are some of the best talks from the largest healthspan conference in the world, which was held for the third time in Riyadh by the Hevolution Foundation.
- [Repurposing Drugs to Lower Dementia Risk](https://www.lifespan.io/news/repurposing-drugs-to-lower-dementia-risk/) - Reviewers analyzed the results of 14 studies that included 139 million people to identify patterns that connect dementia risk to commonly used medications.
- [A Key Protein for Tendon Health](https://www.lifespan.io/news/a-key-protein-for-tendon-health/) - Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons.
- [Junevity Launches to Develop Cell Reset Therapeutics](https://www.lifespan.io/news/junevity-launches-to-develop-cell-reset-therapeutics/) - Junevity, a biotechnology company on a mission to extend lifespan and healthspan by resetting cell damage, today announced $10 million in seed funding.
- [A Potential New Target for Normal Brain Aging](https://www.lifespan.io/news/a-potential-new-target-for-normal-brain-aging/) - Researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice.
- [Probiotics Slow Down Alzheimer’s Disease in Mice](https://www.lifespan.io/news/probiotics-slow-down-alzheimers-disease-in-mice/) - A human-derived probiotic cocktail is meant to protect against Alzheimer’s disease. The treatment improves gut health and reduces inflammation in mice.
- [Creating a Functional Pancreas From Human Cells](https://www.lifespan.io/news/creating-a-functional-pancreas-from-human-cells/) - In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice.
- [Some Stem Cells Remain Youthful With Age](https://www.lifespan.io/news/some-stem-cells-remain-youthful-with-age/) - Some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells, and removing those bad HSCs is beneficial.
- [Phoenix Aerie: The Launchpad for Longevity Pioneers](https://www.lifespan.io/news/phoenix-aerie-the-launchpad-for-longevity-pioneers/) - Phoenix Aerie (P//A), the first-ever co-living house specifically dedicated to enriching, uplifting, and empowering young longevity pioneers, will be launching.
- [How the Yamanaka Factors Affect Female Reproduction in Rats](https://www.lifespan.io/news/how-the-yamanaka-factors-affect-female-reproduction-in-rats/) - The authors of a recent study reported that OSKM therapy in rats results in higher fertility at an older age and allows older rats to have regular cycles.
- [Early Adult Mortality Remains High in the US](https://www.lifespan.io/news/early-adult-mortality-remains-high-in-the-us/) - Mortality among Americans aged 25-44 has risen substantially between 2011 and 2023, and it remains high even after having passed the COVID-related peak.
- [New Nanoparticles for Treating Arthritis](https://www.lifespan.io/news/new-nanoparticles-for-treating-arthritis/) - In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage.
- [Rejuvenation Roundup January 2025](https://www.lifespan.io/news/rejuvenation-roundup-january-2025/) - As rejuvenation research advances from theory to practice, more therapies start making their way into the clinic. January features both mouse and human work.
- [Artificially Grown Tissue Repairs Heart Failure in Monkeys](https://www.lifespan.io/news/artificially-grown-tissue-repairs-heart-failure-in-monkeys/) - German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells and succeeded in rhesus monkeys.
- [Inhibiting a Fundamental Factor in Brain Inflammation](https://www.lifespan.io/news/inhibiting-a-fundamental-factor-in-brain-inflammation/) - Researchers have devised a method of reducing brain inflammation by creating a long-lasting inhibitor of the inflammatory factor NF-κB.
- [Hevolution Foundation Hosts Second Global Healthspan Summit](https://www.lifespan.io/news/hevolution-foundation-hosts-second-global-healthspan-summit/) - On February 4-5, 2025, Hevolution Foundation will hold its second Global Healthspan Summit (GHS) in Riyadh, Saudi Arabia.
- [New Database Lets You Know How Processed Your Food Is](https://www.lifespan.io/news/new-database-lets-you-know-how-processed-your-food-is/) - Scientists have presented GroceryDB, an open-access online database that measures the processing of products sold in three major US grocery chains.
- [Ultrasound as a Tool to Eliminate Senescent Cells](https://www.lifespan.io/news/ultrasound-as-a-tool-to-eliminate-senescent-cells/) - A study suggests that low-intensity pulsed ultrasound can be beneficial in eliminating senescent cells through the recruitment and activation of immune cells.
- [New Drug Eliminates Breast Cancer in Mouse Study](https://www.lifespan.io/news/new-drug-eliminates-breast-cancer-in-a-single-dose/) - Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer.
- [Cyclarity Launches Human Trial to Cure Atherosclerosis](https://www.lifespan.io/news/cyclarity-launches-human-trial-to-cure-atherosclerosis/) - Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human clinical trial for a drug that aims to remove arterial plaques.
- [Restoring Cellular Proliferation Through Exosomes](https://www.lifespan.io/news/restoring-cellular-proliferation-through-exosomes/) - Researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence.
- [Marco Quarta on Cellular Senescence in Aging](https://www.lifespan.io/news/marco-quarta-on-cellular-senescence-in-aging/) - Dr. Marco Quarta runs one of the most interesting start-ups in the longevity field: Rubedo, which utilizes the senolytic approach to cellular senescence.
- [The 3rd Longevity Med Summit Heads to Lisbon in May 2025](https://www.lifespan.io/news/the-3rd-longevity-med-summit-heads-to-lisbon-in-may-2025/) - The Global 3rd Longevity Med Summit for longevity medicine, wellness, and healthcare innovation is set to take place in Lisbon from May 6 to 8, 2025.
- [Maintaining Muscle by Restoring Gut Bacteria](https://www.lifespan.io/news/maintaining-muscle-by-restoring-gut-bacteria/) - In Aging Cell, researchers have described how different combinations of sarcopenia-related gut bacteria impact muscle strength in mice.
- [Fighting Alzheimer's by Helping Neurons Consume Proteins](https://www.lifespan.io/news/fighting-alzheimers-by-helping-neurons-consume-proteins/) - Researchers have found that KIF9, which diminishes with aging, is instrumental in allowing cells to consume harmful proteins and fights Alzheimer's in mice.
- [New Study Links Epigenetic Changes to Genetic Mutations](https://www.lifespan.io/news/new-study-links-epigenetic-changes-to-genetic-mutations/) - A new paper published in Nature Aging suggests that somatic mutations cause significant remodeling of the epigenetic landscape.
- [Cutting-Edge Facility Expands to Support Cancer Therapy](https://www.lifespan.io/news/cutting-edge-facility-expands-to-support-cancer-therapy/) - This expands Roswell Park’s GMP facility to 11,000 square feet, including 20 clean rooms across two buildings and an entire floor within the Cancer Center..
- [Enhancing NAD+ Efficiency by Energizing Sirtuins](https://www.lifespan.io/news/enhancing-nad-efficiency-by-energizing-sirtuins/) - Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+.
- [The Impact of a Human Breast Milk Probiotic on Sarcopenia](https://www.lifespan.io/news/impact-of-a-human-breast-milk-probiotic-on-sarcopenia/) - A recent study linked probiotic-induced gut microbiome and metabolite changes to improved muscle functioning in older sarcopenia patients.
- [A Gut Metabolite Reduces Senescence and Inflammation](https://www.lifespan.io/news/a-gut-metabolite-reduces-senescence-and-inflammation/) - Scientists from LRI and the Buck have published their findings that Urolithin A potently reduces senescence-related markers in human fibroblasts.
- [Cyclarity Launches Human Trial for Atherosclerosis](https://www.lifespan.io/news/cyclarity-launches-human-trial-for-atherosclerosis/) - Cyclarity Therapeutics, a biotechnology company based at the Buck Institute in California, has launched its first human clinical trial.
- [Intermittent Fasting Improves Coordination in Mice](https://www.lifespan.io/news/intermittent-fasting-improves-coordination-in-mice/) - Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination.
- [Cyclarity Therapeutics Secures Approval for Clinical Trial](https://www.lifespan.io/news/cyclarity-therapeutics-secures-approval-for-clinical-trial/) - Cyclarity Therapeutics is pleased to announce regulatory approval to begin its first-in-human clinical trial.
- [Precision Targeting of Senescent Cells](https://www.lifespan.io/news/precision-targeting-of-senescent-cells/) - In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go.
- [Receiving Caloric Restriction Benefits Without Practicing It](https://www.lifespan.io/news/receiving-the-benefits-of-caloric-restriction-without-practicing-it/) - Researchers have found that lithocholic acid, a metabolite found in the serum of calorically restricted mice, can mimic the effects of caloric restriction.
- [Vitalia Co-Founders Announce Split-up](https://www.lifespan.io/news/vitalia-co-founders-announce-split-up/) - Vitalia co-founders Niklas Anzinger and Laurence Ion today announced that they will be leading two new, separate organizations, Viva City and Infinita City.
- [Drinking and Dying: Alcohol as a Risk Factor for Cancer](https://www.lifespan.io/news/drinking-and-dying-alcohol-as-a-risk-factor-for-cancer/) - A new advisory by the US Surgeon General highlights a topic that – as the document itself notes – has been flying mostly under the public’s radar.
- [A Potential Gene Therapy for Hearing Loss](https://www.lifespan.io/news/a-potential-gene-therapy-for-hearing-loss/) - In JCI Insight, researchers have explored the possibility of using gene therapy to restore a crucial protein and repair hearing loss.
- [Rejuvenation Roundup December 2024](https://www.lifespan.io/news/rejuvenation-roundup-december-2024/) - The holiday season is over and the new year is here, and we're back to discussing the one gift that matters the most: biological rejuvenation.
- [Keeping Stem Cells Healthy and Young](https://www.lifespan.io/news/keeping-stem-cells-healthy-and-young/) - A team of researchers has outlined a new approach that uses mRNA to prevent senescence and strengthen mesenchymal stem cells (MSCs) against aging.
- [I Dined with Bryan Johnson and Didn’t Die](https://www.lifespan.io/news/i-dined-with-bryan-johnson-and-didnt-die/) - Don’t Die is a way to say you’re actually not powerless because the entirety of our existence is the collection of all of our behaviors.

## Pages

- [Home](https://www.lifespan.io/) - Lifespan Research Institute is A 501(c)(3) nonprofit organization focused on strategically driving forward science to extend healthy human lifespan – through advocacy, ecosystem building, and direct support of cutting edge research into the root causes of aging.
- [Learn more about donating with Crypto](https://www.lifespan.io/learn-more-about-donating-with-crypto/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [LRI - End of Year Campaign 2025](https://www.lifespan.io/end-of-year-2025/) - Lifespan Research Institute (“LRI”) is a 501(c)(3) nonprofit organization focused on the defeat of age-related disease and the extension of healthy human lifespan – through raising awareness for scientific work addressing the root causes of the aging process, building a thriving ecosystem of mission aligned stakeholders which can be mobilized to strategic action, and spearheading relevant research projects directly.
- [How You Can Help Us Solve Aging - BetterGiving](https://www.lifespan.io/how-you-can-help/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Learn more about donating with Stocks](https://www.lifespan.io/learn-more-about-donating-with-stocks/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Learn more about donating with DAF](https://www.lifespan.io/learn-more-about-donating-with-daf/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Aging And Rejuvenation Research News](https://www.lifespan.io/news/) - Daily news and articles related to aging research and rejuvenation biotechnology to address age-related diseases.
- [Thank You Page](https://www.lifespan.io/thank-you-page/)
- [Post-Baccalaureate](https://www.lifespan.io/education-opportunities/postbacc-fellowship/) - The LRI Post-Baccalaureate Fellowship Program, structured like an advanced internship, not only allows participants to work alongside our scientists with a degree of independence, but also promotes their personal academic and career aspirations. Fellows benefit from a gap year option with career-minded training that often bridges their undergraduate experience to a graduate experience of their choosing (Ph.D., M.D., M.S., or others) or positions within biotech. Like the LRI Summer Scholars Program, the goal of the Post-Baccalaureate Fellowship Program includes assignments and training that hones writing and presentation skills and creates opportunities for participants to strengthen their research and communication skills. These training exercises are completed within the framework of a research project that the Fellow will be tasked with completing under the guidance of a scientific mentor.
- [Summer Scholars](https://www.lifespan.io/education-opportunities/summer-scholars/) - The LRI Summer Scholars Program offers undergraduate students the opportunity to conduct biomedical research to combat diseases of aging, such as cancer, Alzheimer’s, and Parkinson’s Disease. Under the guidance of a scientific mentor, each Summer Scholar is responsible for his or her own research project in such areas as genetic engineering and stem cell research. The Summer Scholars Program emphasizes development of both laboratory and communication skills to develop well-rounded future scientists, healthcare professionals, and policy makers. Students participating in the program will hone their writing skills via periodic reports, which are designed to emulate text scientists commonly must produce. At the end of the summer, students will have the opportunity to put all of their newly developed communication skills into practice at a student symposium.
- [The Longevity Investor Network](https://www.lifespan.io/longevity-investor-network/) - The Longevity Investor Network (LIN) is a global initiative convened by the Lifespan Research Institute to catalyze private investment in biotechnology companies developing interventions that target the root mechanisms of aging. By mobilizing capital and fostering investor education, LIN supports the translation of cutting-edge science into therapies that extend human healthspan.
- [Sharma Lab](https://www.lifespan.io/our-research/sharma-lab/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Team](https://www.lifespan.io/about-us/team/) - Meet the team at Lifespan Research Institute, comprised of mission-driven individuals who work tirelessly towards our goal of ending age-related disease.
- [Become a Sponsor](https://www.lifespan.io/get-involved/lifespan-alliance/) - The Lifespan Alliance unites mission-aligned companies and visionary organizations that believe in the promise of extending healthy human lifespan. By joining, you demonstrate bold leadership in supporting the science, public education, and collaborative ecosystem necessary to address the root causes of aging. Philanthropic support from Alliance members powers the Lifespan Research Institute (LRI) to advance groundbreaking research, engage millions through trusted media, and connect leading voices across science, policy, and technology to accelerate progress.
- [Host Lab Signup](https://www.lifespan.io/education-opportunities/host-lab-signup/) - Lifespan Research Institute has been actively recruiting, admitting, mentoring, and supporting student interns since 2013. To date, we’ve placed 198 students across more than 26 institutions, and we’re always looking to expand. Your lab could be our next host lab!
- [LRI Email Landing Page](https://www.lifespan.io/lri-landing-page/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [LRI Landing Page - Old](https://www.lifespan.io/lri-landing-page-old/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [LysoSENS: Clearing Waste Accumulations Out of Cells](https://www.lifespan.io/our-research/intro-to-sens-research/lysosens/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [GlycoSENS: Breaking Extracellular Crosslinks](https://www.lifespan.io/our-research/intro-to-sens-research/glycosens/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [ApoptoSENS: Removing Dysfunctional Cells](https://www.lifespan.io/our-research/intro-to-sens-research/apoptosens/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Privacy Policy](https://www.lifespan.io/privacy-policy/) - This Privacy Policy describes how and when Lifespan.io collects, uses and shares your information when you use our website and related services.
- [Graduate Programs](https://www.lifespan.io/education-opportunities/graduate-programs/) - Lifespan Research Institute is proud to offer new opportunities for graduate students interested in advancing their careers, gaining experience beyond academia, contributing to impactful longevity research, and reimagining the future of aging. These funded programs are designed to support a wide range of goals and are open to students at every stage of their graduate education.
- [Education Programs Application Form](https://www.lifespan.io/education-opportunities/2025-education-programs-application-form/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Intramural Research](https://www.lifespan.io/our-research/intramural-research/) - The LRI Research Center is our internal research laboratory, and the core of our intramural research efforts. In our lab, researchers undertake proof-of-concept research in rejuvenation biotechnologies, seeking to comprehensively address the disabilities and diseases of aging by repairing the damage done by the aging process at the molecular level.
- [Boominathan Lab](https://www.lifespan.io/our-research/boominathan-lab/) - Dr. Boominathan's lab focuses on identifying translational avenues to combat mitochondrial dysfunction, a major cause of aging and age-related diseases.
- [Our Research](https://www.lifespan.io/our-research/) - The Lifespan Research Institute (LRI) conducts targeted scientific research with the explicit goal of accelerating the development of therapies that address the root causes of aging, leading to the defeat of age-related diseases and the extension of healthy human lifespan. This approach has amazing potential to positively affect the human condition by giving people interventions and treatments that yield more years of healthy, productive life.
- [Get Involved](https://www.lifespan.io/get-involved/) - As the core concepts of rejuvenation biotechnology are accepted by a growing professional audience, LRI continues to build a network of informed and enthusiastic stakeholders. Our outreach efforts form valuable links with organizations and individuals outside of our community to inform the general public, policymakers, industry players, and academia about the promise and challenges of the damage-repair approach to age-related diseases. We do this through our conferences, media interviews, informative videos, speaking engagements, fundraising events, and social media. Please learn about the ways in which you can join our growing community.
- [LRI Publications](https://www.lifespan.io/about/lri-publications/) - Here is the list of publication of the Lifespan Research Institute, and external supported publications.
- [Email Registration](https://www.lifespan.io/email-registration/) - [nextend_social_login_register_flow]
- [About Us](https://www.lifespan.io/about-us/) - Lifespan Research Institute (“LRI”) is a 501(c)(3) nonprofit organization focused on the defeat of age-related disease and the extension of healthy human lifespan – through raising awareness for scientific work addressing the root causes of the aging process, building a thriving ecosystem of mission aligned stakeholders which can be mobilized to strategic action, and spearheading relevant research projects directly.
- [Scientific Advisory Board](https://www.lifespan.io/about-us/research-advisory-board/) - The Lifespan Research Institute Scientific Advisory Board.
- [Ending Age-Related Diseases - Archive](https://www.lifespan.io/resources/ending-age-related-diseases-archive/) - Our Ending Age-Related Diseases (EARD) conference provides its guests with a rich collection of research talks, panel discussions, workshops, interviews, and motivational talks. Solving aging is the greatest challenge humankind has ever faced. To do it, we need a united community working together making it happen. Investors, researchers, journalists, advocates, policymakers, lobbyists, and other participants all need to join together. Our conferences bring entrepreneurs and investors, pharma and biotech companies, researchers, and government organizations together to exchange research reports, inspire and get inspired with new ideas, and find collaborators, supporters, and mentors.
- [Board of Directors](https://www.lifespan.io/about-us/board-of-directors/) - The Lifespan Research Institute Board of Directors.
- [Extramural Research](https://www.lifespan.io/our-research/extramural-research/) - Since its founding in 2009, the establishment and ongoing expansion of our external research program has been a major part of Lifespan Research Institute’s commitment to changing the way the world researches and treats age-related disease. We recognize that building and sustaining collaborations throughout a global research community is crucial to the realization of our mission. Toward this end, we fund work at some of the top universities and research institutions in the world. Learn more about each active project and how it relates to LRI’s mission through the materials in this section.
- [LRI Education Program Alumni](https://www.lifespan.io/education-opportunities/lri-education-program-alumni/) - Lifespan Research Institute supports a variety of student research endeavors, such as the Summer Scholars and Post-Baccalaureate Fellowship Programs, which provide students with the opportunity to learn valuable laboratory and communication skills to become successful scientists.
- [Sponsored Projects](https://www.lifespan.io/advocacy/sponsored-projects/) - Lifespan Research Institute fiscally sponsors on-mission projects driving forward the field of aging research.
- [Engaging the Press](https://www.lifespan.io/advocacy/engaging-the-press/) - A large part of our activities at LRI includes engaging new audiences about the potential of science to end age-related diseases. We are active science advocates and our leadership team has often been featured on network television, news programs, podcasts, and other media, including large-scale news outlets such as Fox News and The Young Turks. If you have a press inquiry or interview requests for our team, please get in touch.
- [Video Initiatives](https://www.lifespan.io/advocacy/video-initiatives/) - One of the most powerful ways to engage and educate the public is by partnering with influential media creators. We have a history of working with top-tier content creators to make videos reaching tens of millions of people, inspiring them to support research to extend healthy human lifespan. We can work together with aligned organizations to create impactful content, and we also maintain our own popular channels which delivers a variety of content such as Journal Club, interviews, mini-documentaries, and advocacy videos.
- [MitoSENS: Preventing Damage from Mitochondrial Mutations](https://www.lifespan.io/our-research/intro-to-sens-research/mitosens/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Education Opportunities](https://www.lifespan.io/education-opportunities/) - LRI Education strives to create a well-trained generation of scientists who are familiar with, and invested in, regenerative medicine. It is the future scientists, doctors, and policy makers of this burgeoning new field who will create the paradigm shift in how academic institutions, pharmaceutical companies, and regulatory agencies look at treating the diseases of aging. We offer several options for students interested in learning more about our mission of preventing age-related diseases.
- [Work With Us](https://www.lifespan.io/get-involved/work-with-us/) - Lifespan Research Institute is at the center of the rejuvenation biotechnology industry and supports the mission to end age-related disease through Research, Education, and Outreach. Make your career something you can believe in – something that can change the world.
- [Resources](https://www.lifespan.io/resources/) - As part of our nonprofit mission at Lifespan Research Institute we create tools and informative resources to share with the public. These include useful infographics, knowledge-base articles, and tools to help you find mission-related events in your area.
- [Advocacy](https://www.lifespan.io/advocacy/) - A core part of our mission at Lifespan Research Institute is engaging the public where they are, on the internet and in their living rooms, and inspiring a societal change to prioritize research to with the ability to keep everyone healthy, longer. To see a future of extended healthy human lifespan and freedom from age-related disease as fast as possible requires buy-in from all members of society: the public, regulators, investors, and you. Just like successful advocates for cancer and AIDS research in the past, we recognize that this all starts with persuading the public that the work of our vitally important field is desirable, ethical, and feasible.
- [Submit a Grant Proposal](https://www.lifespan.io/our-research/submit-a-grant-proposal/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [News Test Page](https://www.lifespan.io/news-test/) - Our mission is to promote the advancement of biomedical technologies which will increase healthy human lifespan and eliminate age-related diseases.
- [News Landing Page](https://www.lifespan.io/longevity-news/)
- [Volunteer for Research](https://www.lifespan.io/our-research/volunteer-for-research/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Intro to SENS Research](https://www.lifespan.io/our-research/intro-to-sens-research/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Annual Reports](https://www.lifespan.io/annual-reports/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [News](https://www.lifespan.io/news-old/) - Daily news and articles related to aging research and rejuvenation biotechnology to address age-related diseases.
- [The Longevity Investor Network](https://www.lifespan.io/longevity-investor-network-2/) - The Longevity Investor Network is a LEAF initiative to bring investors and promising, aging-focused biotech startups together.
- [RepleniSENS: Replacing Lost Cells](https://www.lifespan.io/our-research/intro-to-sens-research/replenisens/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [OncoSENS: Making Cancerous Mutations Harmless](https://www.lifespan.io/our-research/intro-to-sens-research/oncosens/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [AmyloSENS: Removing Junk from Between Cells](https://www.lifespan.io/our-research/intro-to-sens-research/amylosens/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [Investments](https://www.lifespan.io/our-research/investments/) - About Mission Board of Directors Scientific Advisory Board Team Annual Reports Contact Research Internal Research External Research Submit a Grant Proposal Investments Publications Education Summer Scholars Post-Baccalaureate Graduate Programs LRI Education Program Alumni Become a Host Lab News Outlet Latest News Interviews Editorials Op-Ed Rejuvenation Roundup Press Releases Investor Network About Join Reports Advocacy Video
- [The Million-Molecule Challenge](https://www.lifespan.io/sponsor-mmc/) - Ora Biomedical and Dr. Matt Kaeberlein have launched “The million molecule challenge”. It will screen many compounds with the potential to increase longevity.
- [Lifespan Ethics Code of Longevity Journalism](https://www.lifespan.io/ethics-code-of-longevity-journalism/) - We have developed the Ethics Code of Longevity Journalism that can from now on be a guide for all good-faith actors in our community as well as for ourselves.
- [Lifespan.io Sitemap](https://www.lifespan.io/sitemap/) - This is our sitemap, the are many like it, but this one is ours.