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# Alithea Genomics

> Alithea Genomics develops MERCURIUS™ high-throughput RNA-seq library prep kits (DRUG-seq, BRB-seq, FLASH-seq) and RNA-seq services for drug discovery, toxicology and large-scale transcriptomics. Offices in Epalinges, Switzerland and Frederick, MD, USA.

## Sitemaps
- [XML Sitemap](https://alitheagenomics.com/sitemap_index.xml): Includes all crawlable and indexable pages.

## Posts
- [How High-Throughput Transcriptomics Advances AI-Enabled Toxicology](https://alitheagenomics.com/high-throughput-transcriptomics-ai-toxicology/): Learn how high-throughput transcriptomics and AI can improve mechanistic toxicology, tPOD analysis, compound prioritization, and AI-ready safety datasets.
- [Webinar: AI-ready ultra-high-throughput whole transcriptome profiling with MERCURIUS™ 1536 DRUG-seq](https://alitheagenomics.com/webinar-ai-ready-ultra-high-throughput-whole-transcriptome-profiling-with-mercurius-1536-drug-seq/): Webinar: how MERCURIUS™ 1536 DRUG-seq brings whole transcriptome profiling to 1536-well primary screens and large-scale, AI-ready perturbation datasets.
- [Alithea Genomics Launches Early Access Program for MERCURIUS™ 1536 DRUG-seq, Bringing Transcriptomics to Compound Screening Scale](https://alitheagenomics.com/alithea-genomics-launches-early-access-program-for-mercurius-1536-drug-seq-bringing-transcriptomics-to-compound-screening-scale/): Alithea Genomics opens early access to MERCURIUS™ 1536 DRUG-seq, generating transcriptome-wide compound-response data directly from 1536-well plates.
- [Alithea Genomics and Revvity announce distribution agreement to expand access to MERCURIUS™ DRUG-seq solutions](https://alitheagenomics.com/alithea-genomics-and-revvity-announce-distribution-agreement-to-expand-access-to-mercurius-drug-seq-solutions/): Alithea Genomics and Revvity sign a distribution agreement to bring MERCURIUS™ DRUG-seq and Total DRUG-seq to labs through Revvity's global commercial network.
- [High-Throughput Transcriptomic Biomarker and Mechanism of Action Discovery: From Gene Expression Signatures to Clinical Outcomes](https://alitheagenomics.com/high-throughput-transcriptomic-biomarker-and-mechanism-of-action-discovery-from-gene-expression-signatures-to-clinical-outcomes/): Explore how transcriptomic gene expression signatures support biomarker discovery, mechanism-of-action studies, toxicology, and clinical translation.
- [How High-Throughput Transcriptomics Solves the AI Training Data Bottleneck in Drug Discovery ](https://alitheagenomics.com/how-high-throughput-transcriptomics-solves-the-ai-training-data-bottleneck-in-drug-discovery/): Learn how high-throughput transcriptomics can generate perturbation-rich, AI-ready datasets for predictive modeling and AI-enabled drug discovery.
- [SOT Annual Meeting and ToxExpo 2026: Key Themes in Omics-Driven Mechanistic Toxicology to Watch](https://alitheagenomics.com/sot-annual-meeting-and-toxexpo-2026-key-themes-in-omics-driven-mechanistic-toxicology-to-watch/): Discover the key themes from the SOT Annual Meeting and ToxExpo 2026, including transcriptomics, predictive toxicology, AI-driven safety assessment, and the rise of NAMs in toxicology.
- [Alithea Genomics Closes CHF 6.9M Seed Round, Using Proceeds to Unlock Industrial-Scale RNA-seq for Primary Drug Screening and Toxicology](https://alitheagenomics.com/alithea-genomics-closes-chf-6-9-m-seed-round-using-proceeds-to-unlock-industrial-scale-rna-seq-for-primary-drug-screening-and-toxicology/): Alithea Genomics closes its CHF 6.9M seed round, led by Genku Ventures, to bring industrial-scale RNA-seq to primary drug screening and toxicology.
- [Case Study: Combining High-Content Imaging and MERCURIUS™ DRUG-seq to Identify Brain-Penetrant Modulators of Microglial Function ](https://alitheagenomics.com/case-study-combining-high-content-imaging-and-mercurius-drug-seq-to-identify-brain-penetrant-modulators-of-microglial-function/): Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning - McCrea and Batorsky et al.
- [Published DRUG-seq vs MERCURIUS™ DRUG-seq: Key Differences Explained ](https://alitheagenomics.com/published-drug-seq-vs-mercurius-drug-seq-key-differences-explained/): Published DRUG-seq vs MERCURIUS™ DRUG-seq: faster turnaround, higher library efficiency, and plug-and-play scalability for high-throughput screening.
- [DRUG-seq for CRISPR screens](https://alitheagenomics.com/drug-seq-for-crispr-screens/): Among the most innovative applications is the development of DRUG-seq, a powerful tool that combines the precision of CRISPR with the scalability of high-throughput sequencing to screen for genetic interactions at an unprecedented scale.
- [TempO-seq™ for High-Throughput Toxicology: A Case Study](https://alitheagenomics.com/tempo-seq-for-high-throughput-toxicology-a-case-study/): Let’s dive in to see how researchers recently used TempO-seq™ to map response variability in a personalized, large-scale toxicology study, and how other more unbiased, non-targeted approaches like MERCURIUS™ DRUG-seq could provide richer transcriptome-wide data for future studies.
- [Tackling Plastic Waste and CO2 Emissions for Pharma Sustainability: Does Massive Sample Multiplexing Offer a Path to Lab Sustainability? ](https://alitheagenomics.com/tackling-plastic-waste-and-co2-emissions-for-pharma-sustainability-does-massive-sample-multiplexing-offer-a-path-to-lab-sustainability/): Explore RNA-seq multiplexing lab sustainability, including the key workflow, applications, strengths, limitations, and where the approach fits in modern.
- [The OASIS Consortium: Can Multi-Omics Improve Chemical Safety Assessment?](https://alitheagenomics.com/the-oasis-consortium-can-multi-omics-improve-chemical-safety-assessment/): Explore OASIS consortium multi-omics and how omics-based molecular readouts can support mechanistic toxicology, safety assessment, and more informed compound.
- [SPT Labtech and Alithea Genomics Collaborate to Automate Ultra Sensitive Single-Cell Transcriptomic Workflows](https://alitheagenomics.com/spt-labtech-and-alithea-genomics-collaborate-to-automate-ultra-sensitive-single-cell-transcriptomic-workflows/): Cambridge, UK, and Lausanne, Switzerland, 05 November 2025: SPT Labtech, a global leader in the design and development of laboratory automation and liquid handling solutions, and Alithea Genomics, a pioneer…
- [Alithea Genomics Introduces MERCURIUS™ Spheroid DRUG-seq: Extraction-Free, RNA-seq for 3D Drug Screening and Toxicology](https://alitheagenomics.com/alithea-genomics-introduces-mercurius-spheroid-drug-seq-extraction-free-rna-seq-for-3d-drug-screening-and-toxicology/): Alithea Genomics launches MERCURIUS™ Spheroid DRUG-seq, an extraction-free RNA-seq library prep kit for 3D spheroid drug screening and toxicology.
- [Omics in Short-Term Toxicology Studies: Are We Ready to Replace Traditional Approaches?](https://alitheagenomics.com/omics-in-short-term-toxicology-studies-are-we-ready-to-replace-traditional-approaches/): Explore omics short-term toxicology and how omics-based molecular readouts can support mechanistic toxicology, safety assessment, and more informed compound.
- [MERCURIUS™ FLASH-seq vs 10x Genomics Chromium: Which Single-Cell RNA-seq Approach is Right for You? ](https://alitheagenomics.com/mercurius-flash-seq-vs-10x-genomics-chromium-which-single-cell-rna-seq-approach-is-right-for-you/): Compare FLASH-seq and 10x Genomics Chromium for single-cell RNA-seq, including sensitivity, transcript coverage, throughput, and best-fit applications.
- [Opportunities and Challenges of the Connectivity Map and L1000](https://alitheagenomics.com/opportunities-and-challenges-of-the-connectivity-map-and-l1000-gene-expression-profiling/): The Connectivity Map, driven by the L1000 gene expression profiling technology, is a leader in these screening efforts. It aims to provide a comprehensive resource for studying the effects of thousands of compounds on cellular functions and diseases (Subramanian et al., 2017).
- [How Does RASL-seq Compare to  BRB-seq and DRUG-seq](https://alitheagenomics.com/the-strengths-and-weaknesses-of-rasl-seq-compared-to-mercurius-brb-seq-and-mercurius-drug-seq/): Determining the most suitable transcriptomic technology to drive your large-scale compound screen, clinical study, or to assess a panel of genetic perturbations can be a headache, especially if you’re unfamiliar with the strengths and limitations of various sequencing technologies. To ease this headache, in the final installment of our RASL-seq mini-series, we discuss the strengths and weaknesses of RASL-seq and compare it to the more recent mRNA barcoding methods MERCURIUS™ BRB-seq and MERCURIUS™ DRUG-seq to help you decide which to integrate into your next large-scale transcriptomics pipeline.
- [What does ‘high-throughput’ mean in sequencing?](https://alitheagenomics.com/what-does-high-throughput-mean-in-sequencing/): ‘High-throughput’ in sequencing refers to the amount of DNA molecules read at the same time. Learn more about High-throughput in sequencing here.
- [What is Bulk RNA Sequencing (Bulk RNA-seq)?](https://alitheagenomics.com/bulk-rna-seq/): Bulk RNA-seq is a method that allows researchers to measure the expression levels of thousands of genes simultaneously in a sample that contains a mixture of cells, providing an averaged expression profile from a collective of cells.
- [TempO-seq VS MERCURIUS™ DRUG-seq in Compound Screening ](https://alitheagenomics.com/tempo-seq-vs-drug-seq-in-compound-screening/): Compare TempO-seq and DRUG-seq for compound screening, including workflow, transcript coverage, multiplexing, scalability, bias, and cost considerations.
- [What is the difference between Smart-seq2, Smart-seq3, and FLASH-seq for full-length single-cell RNA-seq?  ](https://alitheagenomics.com/what-is-the-difference-between-smart-seq2-smart-seq3-and-flash-seq-for-full-length-single-cell-rna-seq/): Compare Smart-seq2, Smart-seq3, and FLASH-seq for full-length single-cell RNA-seq, including sensitivity, transcript coverage, workflow, and throughput.
- [How to Choose the Right RNA-seq Service Provider for Your Screening Study](https://alitheagenomics.com/how-to-choose-the-right-rna-seq-service-provider-for-your-screening-study/): Learn how to choose an RNA-seq service provider for high-throughput screening, including library prep, sequencing, QC, data delivery, scale, and support.
- [Questions About our RNA-Seq Service? Look No Further!](https://alitheagenomics.com/questions-about-our-rna-seq-service-look-no-further/): Explore RNA-seq service FAQ, including the key workflow, applications, strengths, limitations, and where the approach fits in modern transcriptomics research.
- [Alithea Genomics Announces the Launch of MERCURIUS™ FLASH-seq: A Plate-Based, Full-Length Single Cell RNA-seq Kit Delivering Exceptional Sensitivity and Simplicity](https://alitheagenomics.com/alithea-genomics-announces-the-launch-of-mercurius-flash-seq-a-plate-based-full-length-single-cell-rna-seq-kit-delivering-exceptional-sensitivity-and-simplicity/): Alithea Genomics launches MERCURIUS™ FLASH-seq, a plate-based, full-length single-cell RNA-seq kit built for high sensitivity and a simple workflow.
- [Alithea Genomics Launches MERCURIUS™ Total DRUG-seq: A Next-Generation Full-Length Transcriptome Profiling Platform for High-Throughput Compound Screening and Target Validation](https://alitheagenomics.com/alithea-genomics-launches-mercurius-total-drug-seq-a-next-generation-full-length-transcriptome-profiling-platform-for-high-throughput-compound-screening-and-target-validation/): Alithea Genomics launches MERCURIUS™ Total DRUG-seq, extraction-free full-length transcriptome profiling for compound screening and target validation.
- [TaqMan Gene Expression Assays for Compound Screening. Time for an Omics Upgrade?](https://alitheagenomics.com/taqman-gene-expression-assays-for-compound-screening-time-for-an-omics-upgrade/): However, despite their utility, TaqMan™ gene expression assays limit researchers to assessing ~100 bp-long amplicons of relatively small panels of predefined genes.
- [What are TaqMan Gene Expression Assays?](https://alitheagenomics.com/what-are-taqman-gene-expression-assays/): Learn about TaqMan gene expression assays, how the approach works, its main applications and limitations, and how it compares with scalable RNA-seq workflows.
- [Designing Successful RNA-Seq Experiments for Drug Discovery: A Strategic Approach](https://alitheagenomics.com/designing-successful-rna-seq-experiments-for-drug-discovery-a-strategic-approach/): Read on to learn more about the key factors researchers should consider when planning a new RNA-seq-based experiment, from initial design to downstream data analysis.
- [ Overview of Published 3’ mRNA-seq Workflows: From Early Multiplexing and Beyond](https://alitheagenomics.com/overview-of-published-3-mrna-seq-workflows-from-early-multiplexing-and-beyond/): Let’s dig deep into how MERCURIUS™ BRB-seq and MERCURIUS™ DRUG-seq differ from other published high-throughput 3’ mRNA-seq methods, like HiCAR-seq, Prime-seq, and BOLT-seq, and how they perform compared to standard RNA-seq approaches. 
- [BRB-seq pipeline – downstream analysis best practices](https://alitheagenomics.com/brb-seq-pipeline-downstream-analysis-best-practices/): In this post, we will see briefly how to perform downstream analysis for RNA-seq data. BRB-seq libraries are no different than any other bulk RNA-seq libraries.
- [Published Bulk 3’ mRNA-seq Technologies: Which is Best for Your Next Screen?](https://alitheagenomics.com/published-bulk-3-mrna-seq-technologies-which-is-best-for-your-next-screen/): Here, we provide an overview of 3’ mRNA-seq, highlight the similarities and differences of some recently published methods, and indicate why opting for commercial over ‘home-brew’ options might be better in the long run.
- [Maximizing Drug Discovery with High-Throughput and High-Content Screening](https://alitheagenomics.com/maximizing-drug-discovery-with-high-throughput-and-high-content-screening/): Let’s take a look at the trade-offs between high-content screening and high-throughput screening, where both fields are heading in the big data era, and how increasingly scalable, data-rich high-throughput screening technologies are entering the high-content sphere to allow researchers to ‘have it all’.
- [High-content screening in drug discovery: A brief guide](https://alitheagenomics.com/high-content-screening-in-drug-discovery-a-brief-guide/): Learn how high-content screening is used in drug discovery for phenotypic profiling, compound screening, mechanism-of-action studies, and toxicology.
- [How can pairing the JUMP-Cell Painting Gallery with MERCURIUS™ DRUG-seq help your large-scale drug discovery or toxicology study?](https://alitheagenomics.com/how-can-pairing-the-jump-cell-painting-gallery-with-mercurius-drug-seq-help-your-large-scale-drug-discovery-or-toxicology-study/): Pairing JUMP-Cell Painting Gallery with MERCURIUS™ DRUG-seq helps your large-scale drug discovery or toxicology study
- [Missed Toxicity Signals? Unclear Mechanisms of Action? Can MERCURIUS™ DRUG-seq and Cell Painting De-Risk Drug Discovery?](https://alitheagenomics.com/missed-toxicity-signals-unclear-mechanisms-of-action-can-mercurius-drug-seq-and-cell-painting-de-risk-drug-discovery/): We’ll explore how an ultra-high-throughput, cost-effective, whole transcriptome approach called MERCURIUS™ DRUG-seq combined with Cell Painting could help you reduce false leads, improve initial drug selection, and lower the risk of costly late-stage failures (without breaking the bank).
- [What is JUMP-CP consortium?](https://alitheagenomics.com/what-is-jump-cp-consortium/): Explore JUMP Cell Painting consortium, including the key workflow, applications, strengths, limitations, and where the approach fits in modern transcriptomics.
- [Can Combining Cell Painting and L1000 Accelerate Drug Discovery?](https://alitheagenomics.com/can-combining-cell-painting-and-l1000-accelerate-drug-discovery/): Explore Cell Painting and L1000, including the key workflow, applications, strengths, limitations, and where the approach fits in modern transcriptomics.
- [What is Cell Painting?](https://alitheagenomics.com/what-is-cell-painting/): Learn what Cell Painting is, how morphological profiling works, and how the assay supports phenotypic screening, MoA studies, toxicology, and drug discovery.
- [What is DRUG-seq and What Are Its Benefits in Drug Discovery?](https://alitheagenomics.com/what-is-drug-seq-and-what-are-its-benefits-in-drug-discovery/): DRUG-seq is a cost-effective, high-throughput RNA-seq method for drug discovery. Learn how DRUG-seq and other new technologies can reduce costs.
- [BRB-seq for large scale crop science projects](https://alitheagenomics.com/brb-seq-for-large-scale-crop-science-projects/): The world of crop science is evolving rapidly. New technologies are emerging that promise to revolutionize the field. BRB-seq, or Bulk RNA Barcoding and sequencing, is a high-throughput RNA sequencing method. It allows for the simultaneous processing of multiple RNA samples, making it a cost-effective and scalable solution for large scale projects.
- [Using External RNA Controls Consortium (ERCC) Molecules Enhances Quality Controls and Biological Interpretation in MERCURIUS™ DRUG-seq](https://alitheagenomics.com/using-external-rna-controls-consortium-ercc-molecules-enhances-quality-controls-and-biological-interpretation-in-mercurius-drug-seq/): Explore ERCC spike-ins RNA-seq, including the key workflow, applications, strengths, limitations, and where the approach fits in modern transcriptomics.
- [How PAXgene® and Tempus™ blood tubes influence RNA expression signatures](https://alitheagenomics.com/how-paxgene-and-tempus-blood-tubes-influence-rna-expression-signatures/): Find out how PAXgene® and Tempus™ blood tubes can play a role in influencing RNA expression and what is the best practice for your next whole blood transcriptomics project.
- [What is the Connectivity Map and how can it accelerate drug discovery?](https://alitheagenomics.com/what-is-the-connectivity-map-and-how-can-it-accelerate-drug-discovery/): The Connectivity Map is a large-scale comprehensive catalog of cellular transcriptomic signatures that represent systematic genetic or pharmacologic perturbations of many human disease cell types (Lamb et al., 2006; Subramanian et al., 2017).
- [Functional drug screening: microarray vs RNA-seq](https://alitheagenomics.com/functional-drug-screening-microarray-vs-rna-seq/): There are several sensitive methods for investigating gene expression on a large scale. Learn more about functional drug screening - microarray vs RNA-seq.
- [Blood transcriptomics: sequence deeper or sequence more samples?](https://alitheagenomics.com/blood-transcriptomics-sequence-deeper-or-sequence-more-samples/): This article looks at blood transcriptomics in terms of large-scale RNA-seq studies. The current high costs of RNA-seq pose a trade-off between patient samples and sequencing depth.
- [Whole blood RNA-seq to guide COVID-19 treatment](https://alitheagenomics.com/whole-blood-rna-seq-to-guide-covid-19-treatment/): A look at Whole blood RNA-seq to guide COVID-19 treatment. A look at studies and developments in whole blood RNA-seq.
- [A story of fruit flies, sleep and RNA-seq](https://alitheagenomics.com/a-story-of-fruit-flies-sleep-and-rna-seq/): Life scientists have been using the Drosophila Melanogaster, known as the fruit fly. This article highlights new discoveries of genes with RNA-seq.
- [Single and bulk RNA-seq working together to boost immuno-oncology](https://alitheagenomics.com/single-and-bulk-rna-seq-working-together-to-boost-immuno-oncology/): This article looks at Immunotherapy and how single and bulk RNA-seq work together to boost immuno-oncology.
- [What is BRB-seq?](https://alitheagenomics.com/what-is-brb-seq/): Learn more about what BRB-seq is exactly, how it is an innovative technology, the BRB-seq workflow and the applications of BRB-seq in academia and research
- [BRB-seq vs Truseq](https://alitheagenomics.com/brb-seq-vs-truseq/): We anticipate that RNA-seq could become new basic laboratory practice. Learn more about BRB-seq compared to Truseq in this article.
- [How do BRB-seq pre-processing results look like?](https://alitheagenomics.com/how-do-brb-seq-pre-processing-results-look-like/): In this post, we will see briefly how BRB-seq libraries are processed, and what are the output files that the preprocessing pipeline generates.
- [COVID-19 under the BRB-Seq microscope: A Tale of Two Coronaviruses](https://alitheagenomics.com/covid-19-under-the-brb-seq-microscope-a-tale-of-two-coronaviruses/): One of the most common—and arguably the most biologically relevant—applications of RNA sequencing is the ability to assess differential gene expression (DGE).
- [Large-scale RNA-seq series – Ep.1: RNA-seq helps uncover the genetic regulation of blood cells](https://alitheagenomics.com/ht-transcriptomics-ep-1-large-scale-rna-seq-helps-uncover-the-genetic-regulation-of-blood-cells/): Explore a research case study on blood cell transcriptomics, including the biological question, RNA-seq approach, key findings, and implications for.
- [Large-scale RNA-seq series – Ep.2: Predicting cancer outcomes by estimation of tumor specific total mRNA levels in bulk RNA-seq](https://alitheagenomics.com/large-scale-rna-seq-series-ep-2-predicting-cancer-outcomes-by-estimation-of-tumor-specific-total-mrna-levels-in-bulk-rna-seq/): Explore a research case study on bulk RNA-seq cancer prognosis, including the biological question, RNA-seq approach, key findings, and implications for.
- [BRB-seq in cancer therapeutics: differential gene expression elucidates the molecular mechanisms of high-grade pediatric gliomas](https://alitheagenomics.com/brb-seq-in-cancer-therapeutics-differential-gene-expression-elucidates-the-molecular-mechanisms-of-high-grade-pediatric-gliomas/): Explore a research case study on BRB-seq glioma gene expression, including the biological question, RNA-seq approach, key findings, and implications for.
- [Large-scale RNA-seq series Ep. 4: BRB-seq uncovers novel features of fruit fly embryogenesis](https://alitheagenomics.com/large-scale-rna-seq-series-ep-4-brb-seq-uncovers-novel-features-of-fruit-fly-embryogenesis/): Explore a research case study on BRB-seq Drosophila embryogenesis, including the biological question, RNA-seq approach, key findings, and implications for.
- [Large-scale RNA-seq series – EP.3: ‘Multi-omics’ improves the classification of 33 different cancer types using 10,000 tumor samples.](https://alitheagenomics.com/large-scale-rna-seq-series-ep-3-multi-omics-improves-the-classification-of-33-different-cancer-types-using-10000-tumor-samples/): Explore a research case study on multi-omics cancer classification, including the biological question, RNA-seq approach, key findings, and implications for.
- [Large-scale RNA-seq series – Ep. 5. – Gene expression networks control organ development across species](https://alitheagenomics.com/large-scale-rna-seq-series-ep-5-gene-expression-networks-control-organ-development-across-species/): In Ep. 5 of our Large scale RNA-seq series, we look at Gene expression networks control organ development across species.
- [Large-scale RNA-seq series Ep. 6 – Sex Impacts Gene Expression, but not the way you think!](https://alitheagenomics.com/large-scale-rna-seq-series-ep-6-sex-impacts-gene-expression-but-not-the-way-you-think/): Explore a research case study on sex differences gene expression, including the biological question, RNA-seq approach, key findings, and implications for.
- [How does BRB-seq compare to SCRB-seq?](https://alitheagenomics.com/how-does-brb-seq-compare-to-scrb-seq/): Discover how BRB-seq compares to SCRB-seq? We look at these two sequencing technologies and outline which provides the most superior data.
- [Budgeting for an mRNA-seq project? Here are the main cost drivers to keep an eye on.](https://alitheagenomics.com/budgeting-for-an-mrna-seq-project-here-are-the-main-cost-drivers-to-keep-an-eye-on/): Budgeting for an RNA-seq project? Here are the main cost drivers to keep an eye on including the factors influencing RNA seq prices.
- [DRUG-seq: A Validated Method For Drug Discovery](https://alitheagenomics.com/drug-seq-a-validated-method-for-drug-discovery/): DRUG-seq is a high-throughput RNA-seq method validated for drug discovery. Learn how DRUG-seq can find likely targets, mechanisms of action, and more.
- [Three New High-Throughput Transcriptomic Technologies for Drug Discovery](https://alitheagenomics.com/three-new-high-throughput-transcriptomic-technologies-for-drug-discovery/): DRUG-seq, Combi-seq and BRB-seq are three new high-throughput transcriptomic technologies for drug discovery. Learn how these methods drive drug discovery in more disease areas than ever before.
- [Cost-effective 3’ mRNA-seq technologies: How similar are they?](https://alitheagenomics.com/cost-effective-3-mrna-seq-technologies-how-similar-are-they/): Find out the differences between cost-effective 3' mRNA-seq technologies from Alithea Genomics, Lexogen and QIAGEN.
- [What is High-Throughput RNA-Sequencing?](https://alitheagenomics.com/what-is-high-throughput-rna-sequencing/): High-throughput RNA-sequencing is the use of next-generation sequencing technology to explore the transcriptome of a genome. Learn more here.
- [What is high-throughput gene expression detection?](https://alitheagenomics.com/what-is-high-throughput-detection-of-gene-expression/): The high-throughput detection of gene expression relies on next generation sequencing technologies to assess the level of expression of all genes in the genome.
- [Examples of High-Throughput RNA-seq Technologies](https://alitheagenomics.com/examples-of-high-throughput-rna-seq-technologies/): How high-throughput RNA-seq technologies such as MERCURIUS™ BRB-seq, Lexogen 3' mRNA-seq QuantSeq-Pool & QuantSeq 3’ mRNA-seq library prep kits compare.
- [What Is Whole Blood Transcriptome?](https://alitheagenomics.com/what-is-whole-blood-transcriptome/): Whole blood transcriptome refers to the genome-wide expression of all genes from cells contained in the blood. Find out how novel RNA-seq technologies have the potential to revolutionize non-invasive diagnostic identification of diseases.
- [What Is Blood Transcriptome Sequencing?](https://alitheagenomics.com/what-is-blood-transcriptome-sequencing/): Blood transcriptome sequencing is an RNA-seq based technology that investigates the expression level of all mRNA transcripts contained in the blood.
- [Whole Blood Transcriptome Sequencing With RNA-seq](https://alitheagenomics.com/whole-blood-transcriptome-sequencing-with-rna-seq/): Novel ‘ultra-high-throughput’ RNA-seq technologies generate high-quality transcriptional information from hundreds of whole blood samples simultaneously at lower cost than ever before. Find out how in this article!
- [How to Preserve RNA Quality in Whole Blood Samples](https://alitheagenomics.com/how-to-preserve-rna-quality-in-whole-blood-samples/): Maintaining RNA quality in whole blood samples is key for accurate RNA-seq results for disease diagnosis and prognosis. Learn how to preserve RNA quality in whole blood samples.
- [Benefits of Blood BRB-seq](https://alitheagenomics.com/benefits-of-blood-brb-seq/): Low cost, ultra-high-throughput blood transcriptomics with integrated globin depletion. Find out the benefits of MERCURIUS™ Blood BRB-seq can help your study.
- [Benchmarking Blood BRB-seq and GLOBINclear™](https://alitheagenomics.com/benchmarking-blood-brb-seq-and-globinclear/): Blood BRB-seq blocks globin transcripts as well as GLOBINclear™ and increases the amount of gene candidates for your study. See how these products compare.
- [RNA Preservation Methods to Improve RNA Quality and Quantity](https://alitheagenomics.com/rna-preservation-methods-to-improve-rna-quality-and-quantity/): High-quality RNA is essential for high-throughput RNA-seq. It ensures transcriptomic data is accurate, and reliable, and can drive novel findings and conclusions with confidence. Researchers can now choose from many RNA preservation methods to improve RNA quality and quantity for downstream sequencing applications.
- [How do you convert million reads terminology to gigabytes (GB) in NGS?](https://alitheagenomics.com/how-do-you-convert-million-reads-terminology-to-gigabytes-gb-in-next-generation-sequencing/): How do you convert million reads terminology to gigabytes (Gb) in next-generation sequencing? Use our free tool!
- [How Much RNA is Needed for RNA-seq?](https://alitheagenomics.com/how-much-rna-is-needed-for-rna-seq/): RNA-seq quantifies the genome-wide level of thousands of mRNA transcripts from many samples in a single assay. Researchers can now choose from many next-generation RNA-seq library preparation protocols, and the recommended amount of RNA needed for each of these varies by platform.
- [How does MGI sequencing technology work?](https://alitheagenomics.com/how-does-mgi-sequencing-technology-work/): MGI is a leading provider of innovative high-throughput genetic sequencing solutions. Their sequencing technology, also known as MGISeq, is a next-generation sequencing (NGS) platform that has gained popularity in the genomics research community. MGISeq is known for its high-throughput capabilities, fast turnaround times, and cost-effectiveness, making it an attractive option for large-scale sequencing projects.
- [How do RNA-seq results compare between Illumina and MGI platforms?](https://alitheagenomics.com/how-do-rna-seq-results-compare-between-illumina-and-mgi-sequencing-platforms/): Are MGI sequencing platforms as good as Illumina for your RNA-seq experiments? Find out how Illumina and MGI sequencing platforms compare.
- [Scalability of Illumina and MGI Sequencing Technologies](https://alitheagenomics.com/scalability-of-illumina-and-mgi-sequencing-technologies/): What is the scalability of Illumina and MGI sequencing technologies? Here, we find out how they compare.
- [Illumina TruSeq library prep vs BRB-seq: optimal tradeoff between the number of detected genes and sequencing cost](https://alitheagenomics.com/illumina-truseq-library-prep-versus-mercurius-brb-seq-optimal-tradeoff-between-the-number-of-detected-genes-and-sequencing-cost/): RNA-seq experiments rely on robust library prep stages to generate accurate and reliable transcriptomic data. Different library preparation technologies, such as Illumina TruSeq library prep and MERCURIUS™ BRB-seq, detect similar numbers of expressed genes even at low sequencing depth.
- [How are MERCURIUS™ BRB-seq and DRUG-seq library preps compatible with MGI sequencing?](https://alitheagenomics.com/how-are-mercurius-brb-seq-and-drug-seq-library-preps-compatible-with-mgi-sequencing/): MERCURIUS™ BRB-seq and DRUG-seq library preparations are now compatible with MGI sequencing. This gives researchers maximum flexibility to perform ultra-high-throughput 3’ mRNA-seq experiments where MGI sequencers are available.
- [Shallow Sequencing for Quality Control of Library Preparations](https://alitheagenomics.com/shallow-sequencing-for-quality-control-of-library-preparations/): Shallow sequencing of MERCURIUS™ BRB-seq and MERCURIUS™ DRUG-seq library preparations is a quality control (QC) step to ensure that each multiplexed sample will obtain a uniform number of reads to generate reliable and robust data when the libraries are sequenced deeper.
- [How do our kits for MGI compare to MGIEasy RNA library prep kits?](https://alitheagenomics.com/how-do-mercurius-brb-seq-and-mercurius-drug-seq-library-prep-kits-for-mgi-sequencing-compare-to-mgieasy-rna-library-prep-kits/): The bulk 3’ mRNA MERCURIUS™ BRB-seq and DRUG-seq protocol enable extensive sample multiplexing, which allows researchers to include more biological replicates, experimental conditions, or drug treatments than the standard MGIEasy RNA library prep kit suitable for full-length RNA.
- [What is the LINCS consortium?](https://alitheagenomics.com/what-is-the-lincs-consortium/): The Library of Integrated Network-Based Cellular Signatures (LINCS) consortium from the National Institutes of Health (NIH) is a collective effort to catalog changes in gene expression and other cellular processes that occur when cells undergo genetic or pharmacologic perturbations.
- [What is the L1000 gene expression profiling technology?](https://alitheagenomics.com/what-is-the-l1000-gene-expression-profiling-technology/): L1000 is a high-throughput bead-based gene expression profiling assay that directly measures the mRNA abundance of 978 “landmark” genes selected to represent the diversity of biological pathways and processes in human cells. Researchers use this subset of the transcriptome to computationally infer the expression of an additional 11,350 genes not explicitly measured (Subramanian et al., 2017).
- [What Is RASL-seq and How Can It Contribute to Your Drug Discovery Pipeline?](https://alitheagenomics.com/what-is-rasl-seq-and-how-can-it-contribute-to-your-drug-discovery-pipeline/): In this mini-series, we guide you through a technique called RNA-mediated oligonucleotide Annealing, Selection, and Ligation with next-generation sequencing (RASL-seq) to help you evaluate if it is suitable for your next drug discovery and development pipeline or if other sequencing technologies may be more suitable.
- [How RASL-seq Works](https://alitheagenomics.com/how-rasl-seq-works/): RASL-seq is a cost-effective, targeted, high-throughput sequencing technology developed to help researchers, biotechnology, and pharmaceutical companies streamline the discovery of potential therapeutics of tomorrow with genomics (Li et al., 2012; Li, Qiu and Fu, 2012). In the second installment of our RASL-seq mini-series, we explore the protocol behind the technology.
- [How Has RASL-seq Contributed to Previous Discoveries?](https://alitheagenomics.com/how-has-rasl-seq-contributed-to-previous-discoveries/): RNA-mediated oligonucleotide Annealing, Selection, and Ligation with Next-Gen sequencing (RASL-seq) is a targeted high-throughput RNA-seq-based technology that has contributed to diverse biological discoveries from the identification of novel cancer therapeutics to the broad importance of alternative splicing in human health and disease. The third article in our RASL-seq mini-series looks at how researchers have used this technology to advance our knowledge of fundamental biological and disease processes to accelerate therapeutic discoveries and improve human health ultimately.
- [What is TempO-Seq™?](https://alitheagenomics.com/what-is-tempo-seq/): TempO-Seq™ technology harnesses the power of sample barcoding combined with targeted oligos to allow simultaneous measurements of the expression of hundreds to thousands of genes in up to 6,144 samples in the same sequencing run.
- [How does MERCURIUS™ DRUG-seq compare to TempO-Seq™ and RASL-seq?](https://alitheagenomics.com/how-does-mercurius-drug-seq-compare-to-tempo-seq-and-rasl-seq/): Here we give you an insight into how three recent high-throughput transcriptome profiling technologies compare. We look at how MERCURIUS™ DRUG-seq from Alithea Genomics compares to TempO-Seq™ from BioSpyder™ and RASL-seq.
- [What Are Clariom™ Assays?](https://alitheagenomics.com/what-are-clariom-assays/): Clariom™ assays from Applied Biosystems™ use microarray technology to facilitate broad or targeted transcriptome analysis to identify crucial biomarkers, biological pathways, and complex gene expression signatures suited to diverse user needs.
- [The Clariom™ GO Screen versus MERCURIUS™ DRUG-seq](https://alitheagenomics.com/the-clariom-go-screen-versus-mercurius-drug-seq/): Here, we compare the Clariom™ GO Screen to an ultra-scalable 3’ bulk mRNA-seq method called MERCURIUS™ DRUG-seq from Alithea Genomics, which is an attractive alternative to accelerate the development of new drug compounds with robust, scalable transcriptomic insights.
- [Affymetrix™ GeneChip™ Microarrays: Where is the technology now?](https://alitheagenomics.com/affymetrix-genechip-microarrays-where-is-the-technology-now/): Where do Affymetrix™ GeneChip™ microarrays stand today? An overview of current GeneChip™ transcriptome profiling options, their workflow and limitations.
- [What Are QuantiGene™ Plex Gene Expression Assays?](https://alitheagenomics.com/what-are-quantigene-plex-gene-expression-assays/): In this article, we take a look at the specific features and workflow of QuantiGene™ Plex Gene Expression Assays to provide you with a basis to understand how this biased target-focused technology compares to unbiased gene expression profiling with MERCURIUS™ DRUG-seq discussed in our follow-up article.
- [Looking for an RNA-seq method for degraded RNA? Introducing MERCURIUS™ FFPE-seq](https://alitheagenomics.com/looking-for-an-ffpe-rna-seq-method-for-degraded-rna-introducing-mercurius-ffpe-seq/): MERCURIUS™ formalin-fixed paraffin-embedded sequencing (FFPE-seq) is a scalable and cost-effective full-length bulk RNA sequencing technology optimized for heavily degraded RNA samples with RNA integrity numbers (RIN) as low as 1.
- [What is Ion AmpliSeq™ Targeted Sequencing Technology?](https://alitheagenomics.com/what-is-ion-ampliseq-targeted-sequencing-technology/): Ion AmpliSeq™ from Thermo Fisher Scientific is a targeted PCR-based transcriptome profiling technology that allows users to measure the expression levels of over 20,000 genes, even in challenging low-quantity or degraded RNA samples such as from formalin-fixed paraffin-embedded (FFPE) tissue.
- [How Ion AmpliSeq™ Compares to the MERCURIUS™ Family of Technologies](https://alitheagenomics.com/how-ion-ampliseq-compares-to-the-mercurius-family-of-technologies/): In this article, we discuss how Ion AmpliSeq™ compares to the MERCURIUS™ suite of technologies regarding workflows, sample requirements, multiplexing capacities, and cost per sample.

## Pages
- [Website Terms of Use](https://alitheagenomics.com/website-terms-of-use/): These Terms of Service govern access to and use of the Alithea website and any related online pages made available by Alithea Genomics SA ("Alithea", "we", "us", or "our"). By…
- [Cookie Policy](https://alitheagenomics.com/cookie-policy/): This Cookie Policy explains how Alithea Genomics ("Alithea", "we", "us", or "our") uses cookies and similar technologies on our website.
- [Careers](https://alitheagenomics.com/company/careers/): Help us reveal what is hidden in biology. At Alithea Genomics, scientists, engineers and commercial teams work together to make large-scale transcriptomics accessible to researchers around the world.
- [Sample Dataset Access](https://alitheagenomics.com/contact/sample-dataset-access/): Request access to Alithea Genomics sample datasets generated with MERCURIUS™ RNA-seq technologies.
- [202609 DRUG-seq Data Analysis Webinar](https://alitheagenomics.com/202609-drug-seq-data-analysis-webinar/): A practical guide to processing, quality control and analysis of DRUG-seq data
- [Certified Service Providers](https://alitheagenomics.com/certified-service-providers/): Find trusted service providers certified to perform our workflows, validated through our dedicated quality assessment process
- [1536 DRUG-seq Webinar Registration](https://alitheagenomics.com/news-and-events/1536webinarregistration/): Live webinar: AI-ready ultra-high-throughput whole-transcriptome profiling with MERCURIUS™ 1536 DRUG-seq
- [Distributors](https://alitheagenomics.com/distributors/): Looking to use our kits for your next research project? Our technologies are available worldwide.
- [Download Dataset Files](https://alitheagenomics.com/download-dataset-files/): To have access to the deep-sequenced dataset (31 GB reads per sample) contact us.
- [Download Barcode Files](https://alitheagenomics.com/download-barcode-files/): Download MERCURIUS™ barcode sets (V5 A to V5 D) for 96- and 384-well plates to demultiplex BRB-seq and DRUG-seq libraries.
- [Newsletter](https://alitheagenomics.com/contact/newsletter/): Subscribe to the Alithea Genomics newsletter for product updates, webinars and insights on high-throughput transcriptomics.
- [Barcode Files](https://alitheagenomics.com/contact/barcode-files/): Request the MERCURIUS™ barcode files you need to demultiplex and analyze your BRB-seq and DRUG-seq sequencing data.
- [Product Info](https://alitheagenomics.com/contact/product-info/): Ask for product information on MERCURIUS™ RNA-seq library prep kits. A member of the Alithea Genomics team will be in touch shortly.
- [Datasets Access](https://alitheagenomics.com/contact/datasets-access/): Request access to Alithea Genomics RNA-seq datasets generated with MERCURIUS™ DRUG-seq and BRB-seq technologies.
- [Technology](https://alitheagenomics.com/technology/): Explore the MERCURIUS™ technologies from Alithea Genomics: DRUG-seq, BRB-seq and FLASH-seq for scalable, high-throughput transcriptomics.
- [Converters](https://alitheagenomics.com/converters/): Free sequencing calculators from Alithea Genomics: convert gigabases to million reads and DNA µg to pmol for your NGS experiments.
- [Quote](https://alitheagenomics.com/contact/quote/): Request a quote for MERCURIUS™ RNA-seq library prep kits or RNA-seq services from Alithea Genomics. Our team will get back to you shortly.
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- [News & Events](https://alitheagenomics.com/news-and-events/): News, press releases, webinars and conferences from Alithea Genomics, the company behind MERCURIUS™ high-throughput RNA-seq.
- [BRB-seq](https://alitheagenomics.com/technology/brb-seq/): Unlock the power of unbiased transcriptome profiling with massively multiplexed, ultra-high-content, and high-throughput RNA sequencing.
- [FLASH-seq](https://alitheagenomics.com/technology/flash-seq/): Ultra-sensitive, full-length, and plate-based single-cell and low-input RNA-seq technology for sorted cells or low-input RNA samples
- [Contact](https://alitheagenomics.com/contact/): After submitting this form, a member of our team will be in touch with you shortly.
- [Company](https://alitheagenomics.com/company/): “At Alithea Genomics, we are committed to developing solutions that streamline and simplify the generation of big RNA data, which we believe will constitute the foundation of tomorrow's research and…
- [Library](https://alitheagenomics.com/library/): Explore publications, scientific posters, application notes, webinars, and other resources related to our technologies.
- [Blog](https://alitheagenomics.com/blog-posts/): Articles, case studies and tutorials on high-throughput transcriptomics, DRUG-seq, BRB-seq and RNA-seq for drug discovery and toxicology.
- [DNA µg-to-pmol](https://alitheagenomics.com/converters/dna-%c2%b5g-to-pmol/): Convert a DNA amount in µg to pmol, and pmol to µg, from fragment length, with the resulting molar concentration in nM.
- [Gb-to-million reads](https://alitheagenomics.com/converters/gb-to-million-reads/): Convert sequencing output in gigabases (Gb) to million reads for paired-end or single-end runs at any read length.
- [DRUG-seq](https://alitheagenomics.com/technology/drug-seq/): Learn how MERCURIUS™ DRUG-seq enables extraction-free, high-throughput transcriptomics for compound screening, MoA profiling, toxicology, and AI-ready datasets.
- [Homepage](https://alitheagenomics.com/): Alithea Genomics delivers high-throughput transcriptomics kits and services for scalable RNA-seq, gene expression profiling, compound screening, and discovery research.

## Kits
- [MERCURIUS™ Total Plant BRB-seq Kit](https://alitheagenomics.com/kits/mercurius-total-plant-brb-seq-kit/): Plant total RNA-seq kit with plant-focused rRNA depletion, full-length transcript coverage, and early multiplexing for scalable plant transcriptomics.
- [MERCURIUS™ 1536 DRUG-seq Kit](https://alitheagenomics.com/kits/mercurius-1536-drug-seq-kit/): MERCURIUS™ 1536 DRUG-seq is an automatable, ultra-high-throughput bulk 3’ mRNA-seq technology designed for frozen 2D cell lines and primary cells in 1536-well assay plates. It enables screening teams to build…
- [MERCURIUS™ Total Blood BRB-seq Kit](https://alitheagenomics.com/kits/mercurius-total-blood-brb-seq-kits-blood-rna-seq/): Whole blood RNA-seq kit with inline globin depletion, early multiplexing, and full-length total RNA sequencing from purified blood RNA.
- [Low-input FLASH-seq](https://alitheagenomics.com/kits/mercurius-low-input-flash-seq-kits-ultra-sensitive-and-full-length-library-preparation-kits-for-low-input-rna-samples/): MERCURIUS™ Ultra-sensitive FLASH-seq kits for low-input RNA samples (1 pg–1 ng). Detect 2x more genes with our extraction-free 7.5-hour workflow.
- [MERCURIUS™ Total BRB-seq Kit](https://alitheagenomics.com/kits/mercurius-multiplexed-total-rna-seq-kits-full-length-transcriptome-screening/): Total RNA-seq kit for purified RNA, combining rRNA depletion, full-length transcript coverage, and early multiplexing for scalable whole-transcriptome profiling. Achieve full-length transcript coverage in one streamlined workflow.
- [MERCURIUS™ Single-cell FLASH-seq Kit](https://alitheagenomics.com/kits/mercurius-single-cell-flash-seq-kits-extraction-free-library-preparation-kits/): Full-length single-cell RNA-seq kit for sorted cells, delivering ultra-sensitive gene detection, isoform analysis, rare cell profiling, and plate-based workflows.
- [MERCURIUS™ Spheroid DRUG-seq Kit](https://alitheagenomics.com/kits/spheroid-rna-seq-kit/): Spheroid RNA-seq kit for extraction-free, high-throughput transcriptomic profiling of 3D spheroids and organoids in compound screening and toxicology studies.
- [MERCURIUS™ Total DRUG-seq Kit](https://alitheagenomics.com/kits/mercurius-total-drug-seq-kits-full-length-transcriptome-profiling-for-compound-screening-and-target-validation/): Total DRUG-seq kits for extraction-free total RNA-seq from cells, enabling full-length transcriptome profiling for compound screening and target validation.
- [MERCURIUS™ High-sensitivity BRB-seq Kit](https://alitheagenomics.com/kits/mercurius-high-sensitivity-brb-seq-kit/): MERCURIUS™ high-sensitivity bulk RNA BRB-seq kits for low-input RNA sequencing from as low as 1 ng/well. Process up to 384 library preps with one kit. Compatible with Illumina and AVITI sequencers.
- [MERCURIUS™ Full-Length BRB-seq Kit](https://alitheagenomics.com/kits/mercurius-full-length-brb-seq-kit/): MERCURIUS™ full-length bulk RNA-seq kits deliver complete transcript coverage with precise isoform detection. High-throughput workflow enables same-day processing of multiple RNA samples.
- [MERCURIUS™ BRB-seq Kit](https://alitheagenomics.com/kits/mercurius-brb-seq-kit-bulk-rna-seq-kit/): Bulk RNA-seq kit for cost-effective gene expression profiling from purified RNA, with 3′ mRNA-seq, early multiplexing, and up to 384 samples per workflow.
- [MERCURIUS™ DRUG-seq Kit](https://alitheagenomics.com/kits/drug-seq-kits/): Extraction-free DRUG-seq kit for high-throughput transcriptomic profiling in drug discovery, compound screening, MoA studies, toxicity profiling, and AI-ready datasets.

## Publications
- [Inferring circadian phases and quantifying biological desynchrony across single-cell transcriptomes](https://alitheagenomics.com/publication/inferring-circadian-phases-and-quantifying-biological-desynchrony-across-single-cell-transcriptomes/)
- [Haplotype-phased ‘Ottawa 3’ genome unravels differential reaction of apple rootstock roots to mixed viral infection](https://alitheagenomics.com/publication/haplotype-phased-ottawa-3-genome-unravels-differential-reaction-of-apple-rootstock-roots-to-mixed-viral-infection/)
- [Multi‐well plate lid for single‐step pooling of 96 samples for high‐throughput barcode‐based sequencing.](https://alitheagenomics.com/publication/stephanie-boder%e2%80%90pasche-mustafa-demir-sarah-heub-manon-garzuel-real-ischer-daniel-migliozzi-siegfried-graf-noa-schmid-h-baris-atakan/)
- [A stromal cell population that inhibits adipogenesis in mammalian fat depots.](https://alitheagenomics.com/publication/schwalie-p-c-dong-h-zachara-m-russeil-j-alpern-d-akchiche-n-caprara-c-sun-w-schlaudraff-k-u-soldati-g-wolfrum-c-deplancke-b-2018-a-stromal-cell-population-t/)
- [Cell-cycle inhibition preserves robust development but rebalances lineages in mouse gastruloids.](https://alitheagenomics.com/publication/maxine-leonardi-yves-paychere-felix-naef-cell-cycle-inhibition-preserves-robust-development-but-rebalances-lineages-in-mouse-gastruloids/)
- [Spermidine Reproduces the Anti-Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal-Induced Inflammation.](https://alitheagenomics.com/publication/pham-c-n-castelli-f-finet-f-leroy-c-chollet-c-chirayath-t-w-moitra-s-zarka-m-ostertag-a-brial-f-combes-c-latourte-a-bardin-t-fenaille-f-richette-p-and-ea-h/)
- [MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes.](https://alitheagenomics.com/publication/wu-c-wang-t-ghosh-a-et-al-mtch2-modulates-cpt1-activity-to-regulate-lipid-metabolism-of-adipocytes/)
- [BioSkel – Towards a Framework for OMICS Applications.](https://alitheagenomics.com/publication/valentin-beauvais-clemence-couton-nicolo-tonci-sebastien-limet-lucile-mollet-thierry-prazuck-and-sophie-robert-bioskel-towards-a-framework-for-omics-applications/)
- [Molecular determinants of brain-resident CD8+ T cell formation and function. ](https://alitheagenomics.com/publication/tarek-elmzzahi-chun-hsi-su-mehrnoush-hadaddzadeh-shakiba-doaa-hamada-daryamalko-maren-koehne-aleksej-frolov-teisha-mason-yuanfang-li-rebekka-scholz-collins-osei-sarpong-leonie-heyden-jonas/)
- [Local niche-derived immunosuppressive CXCR2+ cells impair antiviral immunity.](https://alitheagenomics.com/publication/akisawa-satomi-riho-saito-tadahaya-mizuno-hiroki-sugishita-hideki-ukai-shigeyuki-shichino-masashi-yanagisawa-kouji-matsushima-yukiko-gotoh-to/)
- [Fast and highly sensitive full-length single-cell RNA sequencing using FLASH-seq.](https://alitheagenomics.com/publication/hahaut-v-pavlinic-d-carbone-w-et-al-fast-and-highly-sensitive-full-length-single-cell-rna-sequencing-using-flash-seq/)
- [CRIPTO’s multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient data.](https://alitheagenomics.com/publication/rodrigues-sousa-e-de-brot-s-zoni-e-et-al-criptos-multifaceted-role-in-driving-aggressive-prostate-cancer-unveiled-by-in-vivo-organoid-and-patient-data/)
- [Targeting stemness pathways modulates macrophage polarization and reprograms the tumor microenvironment.](https://alitheagenomics.com/publication/austeja-butkute-marius-baltramonaitis-simona-malmige-adas-darinskas-vita-pasukoniene-agata-mlynska-targeting-stemness-pathways-modulates-macrophage-polarization-and-reprograms-the-tumor-microenv/)
- [In Vitro Evaluation of the Safety and Efficacy of Cibisatamab Using Adult Stem Cell-Derived Organoids and Colorectal Cancer Spheroids.](https://alitheagenomics.com/publication/anstett-v-heinzelmann-e-piraino-f-roch-a-chrisnandy-a-norkin-m-garnier-v-homicsko-k-hoehnel-ka-s-brandenberg-n-in-vitro-evaluation-of-the-safety-and-efficacy-of-cibisatama/)
- [Transcriptional landscape of human keratinocyte models exposed to 60-GHz millimeter-waves.](https://alitheagenomics.com/publication/catherine-martin-bertrand-evrard-frederic-percevault-kate-ryder-thomas-darde-aurelie-lardenois-maxim-zhadobov-ronan-sauleau-frederic-chalmel-yves/)
- [Sustained Vascular Inflammatory Effects of SARS‑CoV‑2 Spike Protein on Human Endothelial Cells.](https://alitheagenomics.com/publication/mitra-gultom-lin-lin-camilla-blunk-brandt-anastasia-milusev-alain-despont-jane-shaw-yvonne-doring-yonglun-luo-robert-rieben-sustained-vascular-inflammatory-effects-of-sars/)
- [Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.](https://alitheagenomics.com/publication/przystal-j-m-cianciolo-cosentino-c-yadavilli-s-zhang-j-laternser-s-bonner-e-r-prasad-r-dawood-a-a-lobeto-n-chin-chong-w-biery-m-c-myers-c-olson-j-m-panditha/)
- [Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells.](https://alitheagenomics.com/publication/mouri-k-guo-m-h-de-boer-c-g-lissner-m-m-harten-i-a-newby-g-a-deberg-h-a-platt-w-f-gentili-m-liu-d-r-campbell-d-j-hacohen-n-tewhey-r-ray-j-p-202/)
- [Time-resolved characterization of the innate immune response in the respiratory epithelium of human, porcine, and bovine during influenza virus infection.](https://alitheagenomics.com/publication/laloli-l-licheri-m-f-probst-l-licheri-m-gultom-m-holwerda-m-vkovski-p-dijkman-r-2022-time-resolved-characterization-of-the-innate-immune-response-in-the-respira/)
- [Katarina Pinjusic, Giovanna Ambrosini, Joao Lourenco, Nadine Fournier, Christian Iseli, Nicolas Guex, Olga Egorova, Sina Nassiri and Daniel B. Constam. Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING.](https://alitheagenomics.com/publication/katarina-pinjusic-giovanna-ambrosini-joao-lourenco-nadine-fournier-christian-iseli-nicolas-guex-olga-egorova-sina-nassiri-and-daniel-b-constam-inhibition-of-anti-tumor-immunity-by-melanoma-ce/)
- [Radiana Ferrero, Pernille Yde Rainer, Marie Rumpler, Julie Russeil, Magda Zachara, Joern Pezoldt, Guido van Mierlo, Vincent Gardeux, Wouter Saelens, Daniel Alpern, Lucie Favre, Nathalie Vionnet, Styliani Mantziari, Tobias Zingg, Nelly Pitteloud, Michel Suter, Maurice Matter, Kai-Uwe Schlaudraff, Carles Canto, and Bart Deplancke. A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.](https://alitheagenomics.com/publication/radiana-ferrero-pernille-yde-rainer-marie-rumpler-julie-russeil-magda-zachara-joern-pezoldt-guido-van-mierlo-vincent-gardeux-wouter-saelens-daniel-2/)
- [Radiana Ferrero, Pernille Yde Rainer, Marie Rumpler, Julie Russeil, Magda Zachara, Joern Pezoldt, Guido van Mierlo, Vincent Gardeux, Wouter Saelens, Daniel Alpern, Lucie Favre, Nathalie Vionnet, Styliani Mantziari, Tobias Zingg, Nelly Pitteloud, Michel Suter, Maurice Matter, Kai-Uwe Schlaudraff, Carles Canto, and Bart Deplancke. A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.](https://alitheagenomics.com/publication/radiana-ferrero-pernille-yde-rainer-marie-rumpler-julie-russeil-magda-zachara-joern-pezoldt-guido-van-mierlo-vincent-gardeux-wouter-saelens-daniel/)
- [Transcriptomic profiling of the response to excess iodide in Keap1 hypomorphic mice reveals new gene-environment interactions in thyroid homeostasis.](https://alitheagenomics.com/publication/panos-g-ziros-dionysios-v-chartoumpekis-ilias-georgakopoulos-soares-georgios-psarias-gerasimos-p-sykiotis-transcriptomic-profiling-of-the-response-to-excess-iodide-in-keap1-hypomorphic-mice-re/)
- [Multiscale physiological responses to nitrogen supplementation of maize hybrids.](https://alitheagenomics.com/publication/sheng-ying-brandon-webster-lina-gomez-cano-kiran-kumar-shivaiah-qianjie-wang-linsey-newton-erich-grotewold-addie-thompson-and-peter-k-lundquist-multiscale-physiological-responses-to-nitrogen/)
- [CRISPR‑Cas9 genetic screen leads to the discovery of L‑Moses, a KAT2B inhibitor that attenuates Tunicamycin‑mediated neuronal cell death.](https://alitheagenomics.com/publication/sofa-pavlou-stefanie-foskolou-nikolaos-patikas-sarah-f-field-evangelia-k-papachristou-clive-d-santos-abigail-r-edwards-kamal-kishore-rizwan-ansari-sandeep-s-rajan-hugo-j-r-fer/)
- [Measuring transcription factor binding and gene expression using barcoded self-reporting transposon calling cards and transcriptomes.](https://alitheagenomics.com/publication/lalli-m-yen-a-thopte-u-dong-f-moudgil-a-chen-x-milbrandt-j-dougherty-joseph-d-mitra-robi-d-2022-measuring-transcription-factor-binding-and-gene-expression-us/)
- [Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma.](https://alitheagenomics.com/publication/christian-w-t-tiphaine-o-m-nava-e-christian-h-federico-a-s-jonathan-n-dominique-c-cecile-g-laurence-m-sophia-s-w-shehnaz-k-h-ioannis-t-matthias-c-andri-r/)
- [Extensive tissue-specific expression variation and novel regulators underlying circadian behavior.](https://alitheagenomics.com/publication/litovchenko-m-meireles-filho-a-c-a-frochaux-m-v-bevers-r-p-j-prunotto-a-anduaga-a-m-hollis-b-gardeux-v-braman-v-s-russeil-j-m-c-kadener-s-dal-peraro-m-amp/)
- [Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning.](https://alitheagenomics.com/publication/li-y-schwalie-p-c-bast-habersbrunner-a-mocek-s-russeil-j-fromme-t-deplancke-b-klingenspor-m-2019-systems-genetics-based-inference-of-a-core-regulatory-network-underlying/)
- [Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant.](https://alitheagenomics.com/publication/hirai-s-tomimatsu-k-miyawaki-kuwakado-a-takizawa-y-komatsu-t-tachibana-t-fukushima-y-takeda-y-negishi-l-kujirai-t-koyama-m-ohkawa-y-kurumizaka-h-2021-unusu/)
- [Profiling the Atopic Dermatitis Epidermal Transcriptome by Tape Stripping and BRB-seq.](https://alitheagenomics.com/publication/hu-t-todberg-t-andersen-d-danneskiold-samsoe-n-b-hansen-s-b-n-kristiansen-k-ewald-d-a-brix-s-rosa-j-c-d-hoof-i-skov-l-litman-t-2022-profiling-the-atopic/)
- [Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress.](https://alitheagenomics.com/publication/weger-m-alpern-d-cherix-a-ghosal-s-grosse-j-russeil-j-gruetter-r-de-kloet-e-r-deplancke-b-sandi-c-2020-mitochondrial-gene-signature-in-the-prefrontal-cortex-for-di/)
- [The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression.](https://alitheagenomics.com/publication/kaya-copur-a-marchiano-f-hein-m-y-alpern-d-russeil-j-luis-n-m-mann-m-deplancke-b-habermann-b-h-schnorrer-f-2021-the-hippo-pathway-controls-myofibril-assembly-and/)
- [Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo.](https://alitheagenomics.com/publication/liu-j-frochaux-m-gardeux-v-deplancke-b-robinson-rechavi-m-2020-inter-embryo-gene-expression-variability-recapitulates-the-hourglass-pattern-of-evo-devo/)
- [Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress.](https://alitheagenomics.com/publication/ma-d-bou-sleiman-m-joncour-p-indelicato-c-e-frochaux-m-braman-v-litovchenko-m-storelli-g-deplancke-b-leulier-f-2019-commensal-gut-bacteria-buffer-the-impact-of-hos/)
- [Sex-dependent and sex-independent regulatory systems of size variation in natural populations.](https://alitheagenomics.com/publication/okada-h-yagi-r-gardeux-v-deplancke-b-hafen-e-2019-sex-dependent-and-sex-independent-regulatory-systems-of-size-variation-in-natural-populations/)
- [LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis.](https://alitheagenomics.com/publication/bast-habersbrunner-a-kiefer-c-weber-p-fromme-t-schiesl-a-schwalie-p-c-deplancke-b-li-y-klingenspor-m-2021-lncrna-ctcflos-orchestrates-transcription-and-alternative-sp/)
- [Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel.](https://alitheagenomics.com/publication/bevers-r-p-j-litovchenko-m-kapopoulou-a-braman-v-s-robinson-m-r-auwerx-j-hollis-b-deplancke-b-2019-mitochondrial-haplotypes-affect-metabolic-phenotypes-in-the-drosoph/)
- [Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction.](https://alitheagenomics.com/publication/giacosa-s-pillet-c-seraudie-i-guyon-l-wallez-y-roelants-c-battail-c-evrard-b-chalmel-f-barette-c-soleilhac-e-fauvarque-m-o-franquet-q-sarrazin-c-peilleron-n/)
- [Cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel.](https://alitheagenomics.com/publication/frochaux-m-v-bou-sleiman-m-gardeux-v-dainese-r-hollis-b-litovchenko-m-braman-v-s-andreani-t-osman-d-deplancke-b-2020-cis-regulatory-variation-modulates-susceptibi/)
- [Distinct Gene Set Enrichment Profiles in Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Bulk RNA Barcoding and Sequencing.](https://alitheagenomics.com/publication/ishino-t-takeno-s-takemoto-k-yamato-k-oda-t-nishida-m-horibe-y-chikuie-n-kono-t-taruya-t-hamamoto-t-ueda-t-2022-distinct-gene-set-enrichment-profiles-in-eosin/)
- [Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas.](https://alitheagenomics.com/publication/yuan-c-pan-z-zhao-k-li-j-sheng-z-yao-x-liu-h-zhang-x-yang-y-yu-d-zhang-y-xu-y-zhang-z-y-huang-t-liu-w-ouyang-h-2020-classification-of-four-distin/)

## Services
- [Total Plant BRB-seq Service](https://alitheagenomics.com/services/total-plant-brb-seq/): Plant RNA-seq service for purified plant RNA, with rRNA depletion, full-length coverage, sequencing, QC and gene count matrices from Alithea.
- [Total Blood BRB-seq](https://alitheagenomics.com/services/total-blood-brb-seq-whole-blood-rna-seq-service/): Whole blood RNA-seq service with integrated globin depletion, full-length total RNA sequencing, QC, sequencing, and gene count matrices from blood RNA.
- [Total BRB-seq](https://alitheagenomics.com/services/multiplexed-total-rna-seq-services-rna-seq-service-alithea-genomics/): MERCURIUS™ bulk RNA-seq service for full-length and total RNA projects of any size. Process 96 purified RNA samples in one tube with fast six-week turnaround and consistent, high-quality results.
- [Low-input FLASH-seq](https://alitheagenomics.com/services/low-input-flash-seq-service-ultra-sensitive-and-full-length-low-input-rna-seq-service-alithea-genomics/): MERCURIUS™ ultra-low input RNA-seq service for ultra-sensitive full-length mRNA sequencing from 1pg to 1ng. Detects up  to 2x more genes than other commercially available solutions.
- [Spheroid DRUG-seq](https://alitheagenomics.com/services/organoid-drug-seq/): Spheroid DRUG-seq service: extraction-free, highly multiplexed RNA-seq on 3D spheroids and organoids for compound screening, toxicology and MoA studies.
- [High-sensitivity BRB-seq ](https://alitheagenomics.com/services/high-sensitivity-low-input-brb-seq/): MERCURIUS™ high sensitivity bulk RNA-seq service compatible with low-input RNA, from as little as 100 pg. Process 48–10,000+ samples with fast 6-week turnaround.
- [Full-length BRB-seq](https://alitheagenomics.com/services/multiplexed-rna-seq-mrna-service/): MERCURIUS™ bulk mRNA-seq service with full transcript coverage and isoform detection. Process 96 samples per tube from purified RNA to data in 6 weeks. Includes QC, sequencing, and gene count matrices.
- [BRB-seq](https://alitheagenomics.com/services/brb-seq/): MERCURIUS™ bulk RNA-seq service from samples to data in 3 weeks. Process 48-10,000+ RNA samples with bulk RNA sequencing at scale. Includes QC, sequencing, alignment reports, and gene count matrices.
- [Single-cell FLASH-seq](https://alitheagenomics.com/services/single-cell-flash-seq-service-ultra-sensitive-and-full-length-single-cell-sequencing/): Single-cell RNA-seq service for sorted cells, delivering full-length transcript coverage, ultra-sensitive gene detection, rare cell profiling, QC, and data delivery.
- [Total DRUG-seq](https://alitheagenomics.com/services/total-drug-seq-services-rna-seq-service-alithea-genomics/): High-throughput total RNA-seq service using Total DRUG-seq for extraction-free, full-length transcriptome profiling from cell plates, including sequencing and QC.
- [DRUG-seq](https://alitheagenomics.com/services/drug-seq/): High-throughput RNA-seq service for compound screening, MoA studies, and toxicity profiling, with extraction-free DRUG-seq library prep, sequencing, QC, and gene count matrices.